Fluorescent dyes and biological and analytical uses thereof

Details Fluorescent dyes and biological and analytical uses thereof Fluorescent dyes and biological and analytical uses thereof

1988-12-02

1990-05-22

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07C 9718, C07C 5022, C07C 5038

Patent

active

049279270

ABSTRACT:
Substituted 4-oxo-4H-benz-[d,e]anthracenes are fluorescent dyes which are useful in biomedical studies and analytical determinations. They are particularly useful in assays for living organisms, e.g. microorganisms, carried out at a pH of 9 or less. For these determinations, the fluorescent dyes can be attached to reducible compounds which will release the dye upon reduction. Alternatively, these dyes can be used in assays for hydrolytic enzymes or biological cells containing these enzymes. For these determinations, the dyes are attached to blocking groups.

REFERENCES:
patent: 4036859 (1977-07-01), Ribaldone et al.
patent: 4296043 (1981-10-01), Schroeder
Cooke et al., Aust. J. Chem., 11, pp. 230-235 (1958).
Cooke et al., Aust. J. Chem. 28, pp. 1053-1057 (1975).
Cooke et al., Aust. J. Chem. 30, pp. 2241-2247 (1977).
Cooke et al., Aust. J. Chem., 32, pp. 1841-1847 (1979).
Chaffee et al., Aust. J. Chem. 34, pp. 587-598 (1981).

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