Fluorescent dyes

Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfonic acids or salts thereof

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558 48, 558176, 562 11, 562 16, 562 37, 562440, C07C22918, C07F 909

Patent

active

050269054

ABSTRACT:
The present invention describes a class of dyes for use in staining cell samples and methods of making such dyes. A preferred class of dyes known as detergent dyes which possess the ability to stain cells in whole blood and are only slowly leached or lost from the stained cells over time are described. The present invention has application, for example, to blood typing for the determination of the presence of blood group antigens A, B, AB, O, and D (Rh.sub.o) and antibodies to such antigens.

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Liebesking et al., "Journal Org. Chem.", 53:2482-88, (1988).
Springer et al., "Ang. Chem. Intl. Edit.", vol. 7:530, (1968).
Kim et al., "J. Chem. Soc., Chem. Commun.", :1201, (1987).
Sprenger et al., "Angew. Chem. Intl. Edit.", vol. 5:894, (1966).

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