Fluorescent dye

Details Fluorescent dye Fluorescent dye

1998-02-02

1999-09-28

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435968, 435 6, 435 772, 435 78, 435 14, 435 23, 435 24, 536 172, 536 173, 536 177, 536 187, C12Q 100, C12Q 168, G01N 3353

Patent

active

059586737

ABSTRACT:
Fluorescent dyes possess reactive linkers for conjugating to nucleic acids, carbohydrates and peptides. The conjugates fluoresce in the visible and UV spectrum and have an excellant solvochromatic response as compared to other fluorescence or chromatic labels. The conjugates are stable but also have medium sensitive. The fluorescent dyes have little triplet state formation and are not photoreactive, making them an excellent substance for biological investigations. Uses for the dyes include protein labelling, DNA labelling, single molecule spectroscopy and fluorescence. A synthesis of the dyes is disclosed. Methods of use include the detection of carbohydrate-protein interactions.

REFERENCES:
patent: 4140529 (1979-02-01), Pai et al.
patent: 4265990 (1981-05-01), Stolka et al.
patent: 5179467 (1993-01-01), Buchwalter et al.

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