Fluorescent conjugates of metal-chelating nitrogen heterocycles

Details Fluorescent conjugates of metal-chelating nitrogen heterocycles Fluorescent conjugates of metal-chelating nitrogen heterocycles

1997-02-07

2000-01-11

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 42, 546 47, 546256, 546257, 546266, 5462681, 5462817, C07D40100

Patent

active

060138025

ABSTRACT:
The present invention describes a family of fluorescent indicators for metal cations. The indicators are fluorophore conjugates of pyridyl-based metal ion chelators. The indicators are very sensitive detection as quantification reagents for a variety of metals, in a variety of oxidation states, even in the presence of high concentrations of Ca.sup.2+, Na.sup.+, or K.sup.+ or other ions, such as is found in seawater, making them highly useful for assaying physiological samples, biological samples, or environmental samples.

REFERENCES:
patent: 4603209 (1986-07-01), Tsien et al.
patent: 4774339 (1988-09-01), Haugland et al.
patent: 4849362 (1989-07-01), DeMarinis et al.
patent: 4945171 (1990-07-01), Haugland et al.
patent: 5049673 (1991-09-01), Tsien et al.
patent: 5134232 (1992-07-01), Tsien et al.
patent: 5135717 (1992-08-01), Renzoni et al.
patent: 5227487 (1993-07-01), Haugland et al.
patent: 5268486 (1993-12-01), Waggoner et al.
patent: 5274113 (1993-12-01), Kang et al.
patent: 5405975 (1995-04-01), Kuhn et al.
patent: 5433896 (1995-07-01), Kang et al.
patent: 5453517 (1995-09-01), Kuhn et al.
patent: 5459276 (1995-10-01), Kuhn et al.
patent: 5501980 (1996-03-01), Katerinopoulos et al.
Martel, et al., Critical Stability Constants, vol. 1, Plenum Press, New York (1974).
Guilbault, Practical Fluorescence, 2.sup.nd Ed., Marcel Dekker, Pub. (1990).
Haugland, Molecular Probes Handbook of Fluorescent Probes and Research Chemicals (1992).
Bissel, et al., Chem. Soc. Rev. 187 (1992).
Brinkley, Bioconj. Chem. 3,2 (1992).
Org. Synth 2, 15 (1943).

Affiliated with

Also associated with

Rating

Fluorescent conjugates of metal-chelating nitrogen heterocycles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorescent conjugates of metal-chelating nitrogen heterocycles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorescent conjugates of metal-chelating nitrogen heterocycles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1463525