Fluorescent compounds for tagging nucleic acid probes

Details Fluorescent compounds for tagging nucleic acid probes Fluorescent compounds for tagging nucleic acid probes

1989-03-14

1992-07-14

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549227, 435 6, C07D31182

Patent

active

051304465

ABSTRACT:
Fluorescent linker moieties are provided which comprise a fluorescent compound such as fluorescein attached to a linker moiety such that a functional group of the linker is available for attachment to an affinity molecule such as a nucleic acid which has an N.sup.4 (substituted amino) cytosine moiety. Probes tagged with fluorescent derivatives such as fluorescein, tetramethyrhodamine or tetraethylrhodamine may be detected by fluorescence spectroscopic methods.

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J. G. J. Bauman et al., "Cytochemical Hybridization with Fluorochrome-labeled RNA I," J. Histochem. Cytochem. 29, 227-237 (1981).
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