Fluorescent cobalamins and uses thereof

Details Fluorescent cobalamins and uses thereof Fluorescent cobalamins and uses thereof

2005-06-14

2005-06-14

Wilson, James O. (Department: 1623)

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

C514S052000, C536S026440

Reexamination Certificate

active

06905884

ABSTRACT:
The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.

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