Fluorescent amino acid derivatives

Details Fluorescent amino acid derivatives Fluorescent amino acid derivatives

2011-04-19

2011-04-19

Aulakh, Charanjit S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C530S350000, C530S331000, C514S002100

Reexamination Certificate

active

07928236

ABSTRACT:
The subject of the present invention is to provide a fluorescent substance excitable under visible light, having higher photostability and a long fluorescence lifetime. Another subject is to provide a fluorescent substance consists of a non-natural amino acid applicable to peptide synthesis systems.Searching fluorescent substances, which are fluorescent amino acids and excitable under visible light, having the lowest possible molecular weight for a high photostability resulted in forming a condensed polycyclic aromatic compound by subjecting a compound having an acridone structure to substitution with an amino acid and further condensation with a benzene ring. Thus, the subject is achieved by the fluorescent substance consisting of amino acid-substituted benzoacridone derivative excitable under visible light.

REFERENCES:
patent: WO 02/099424 (2002-12-01), None
Szymanska et al., “Synthesis of N-[(tert-Butoxy)carbonyl]-3-(9,10-dihydro-9-oxoacridin-2-yl)-L-alanine, a New Fluorescent Amino Acid Derivative,” Helvetica Chimica ACTA, vol. 86 (2003) pp. 3326-3331.
International Preliminary Report on Patentability (in English) for PCT/JP2006/311561 dated Dec. 27, 2007.

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