Optics: measuring and testing – By polarized light examination – With polariscopes
Reexamination Certificate
2003-11-05
2008-08-05
Minnifield, N. M. (Department: 1645)
Optics: measuring and testing
By polarized light examination
With polariscopes
C356S300000, C356S364000, C435S283100, C435S287100, C435S287200
Reexamination Certificate
active
07408640
ABSTRACT:
The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said test sample produced by binding of said fluorescence-labeled ligand to said biological substance. In one aspect of the inventive subject matter, said method comprises additional steps for comparing the fluorescence polarization of said test sample with the fluorescence polarization of a control solution. Also provided is a miniaturized, portable apparatus for measuring the fluorescence polarization of a liquid sample.
REFERENCES:
patent: 4516856 (1985-05-01), Popelka
patent: 6052187 (2000-04-01), Krishnan et al.
Cullum Malford E.
Lininger Linda A.
McArthur Alan L.
Schade Sylvia Z.
Simonson Lloyd G.
Ford Vanessa L
Hemby Joseph K.
Minnifield N. M.
The United States of America as represented by the Secretary of
Yang Ning
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