Chemistry: analytical and immunological testing – Involving producing or treating antigen or hapten – Producing labeled antigens
Patent
1987-02-03
1989-09-19
Nucker, Christine M.
Chemistry: analytical and immunological testing
Involving producing or treating antigen or hapten
Producing labeled antigens
436 56, 436501, 436808, 436816, 436901, 422 61, G01N 33533
Patent
active
048681326
ABSTRACT:
This disclosure relates to a method and reagents for determining amphetamine and methamphetamine in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as .beta.-hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4.0 to about 7.5 without adjustment to an alkaline pH.
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Byrnes Paul J.
Martinus Janis A.
Molina Cynthia M.
Smith Catherine M.
Vaughan Kenward S.
Abbott Laboratories
Griffith Jr. D. John
Hastreiter Roberta L.
Kowalchyk Alan W.
Nucker Christine M.
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