Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation
Reexamination Certificate
2003-05-28
2008-11-18
Lauchman, L. G (Department: 2877)
Optics: measuring and testing
By dispersed light spectroscopy
With sample excitation
C250S459100, C250S458100
Reexamination Certificate
active
07453567
ABSTRACT:
Pulse excitation light, emitted from a laser light source10, is scanned in a first direction by a first scanning means100, scanned in a second direction, perpendicular to the first direction, by a second scanning means120, converged by an objective optical system140, and illuminated onto sample50. Fluorescences, emitted from sample50, are output from objective optical system140to second scanning means120, scanned in the second direction, perpendicular to the first direction, and output to a light separation means110by second scanning means120, output from light separation means110to a streak camera, and recorded as variations of time of the fluorescence intensities by streak camera30. Fluorescence lifetimes are calculated based on these variations with time of the fluorescence intensities and a fluorescence lifetime distribution image is prepared.
REFERENCES:
patent: 5323008 (1994-06-01), Studholme et al.
patent: 5418371 (1995-05-01), Aslund et al.
patent: 6134002 (2000-10-01), Stimson et al.
patent: 6321111 (2001-11-01), Perelman et al.
patent: 6496267 (2002-12-01), Takaoka
patent: 6879394 (2005-04-01), Amblard et al.
patent: 6958858 (2005-10-01), Engelhardt et al.
patent: 7002162 (2006-02-01), Fujimoto et al.
patent: 2 231 958 (1990-11-01), None
patent: 2 323 237 (1998-09-01), None
patent: 59-104519 (1984-06-01), None
patent: 1-227948 (1989-09-01), None
patent: 11-118716 (1999-04-01), None
patent: 2000-088751 (2000-03-01), None
patent: 2001-194305 (2001-07-01), None
patent: 2001-356272 (2001-12-01), None
patent: WO 02/10727 (2002-02-01), None
Wang, X.F. et al., “Fluorescence Lifetime Imaging Microscopy (FLIM): Instrumentation and Applications”, Critical Reviews in Analytical Chemistry, 23 (5):369-395 (1992).
Sytsma, J. et al., “Time-Gated Fluorescence Lifetime Imaging and Microvolume Spectroscopy Using Two-Photon Excitation”, Journal of Microscopy, 191:39-51 (Jul. 1998).
Ossler, F. et al., “Two-Dimensional Visualization of Fluorescence Lifetimes by Use of a Picosecond Laser and a Streak Camera”, Applied Optics, 37 (12):2303-2314 (Apr. 1998).
Saitoh Haruhisa
Terada Hirotoshi
Drinker Biddle & Reath LLP
Hamamatsu Photonics K.K.
Lauchman L. G
LandOfFree
Fluorescence lifetime distribution image measuring system... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fluorescence lifetime distribution image measuring system..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorescence lifetime distribution image measuring system... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4029850