Fluorescence imaging system having reduced background fluorescen

Details Fluorescence imaging system having reduced background fluorescen Fluorescence imaging system having reduced background fluorescen

1997-01-30

1998-12-08

Hannaher, Constantine

Radiant energy

Luminophor irradiation

2504611, 2504612, G01N 2164

Patent

active

058474005

ABSTRACT:
A coaxial illumination and collection laser scanning system designed to provide increased sensitivity by reducing auto-fluorescence while having a substantially uniform detection sensitivity across the field of view of an objective lens by reducing lateral chromatic aberrations at the expense of amplifying axial chromatic aberrations. Axial chromatic aberrations in the system are removed in the path of a retro-beam. A laser is in optical communication with the objective lens. The laser produces a collimated beam of coherent light that is directed by a scanner through the objective lens to illuminate a raster of spots on the sample's surface, thereby stimulating a series of small regions of the sample to emit light. The system may be used as a confocal or non-confocal imaging system.

REFERENCES:
patent: 4006360 (1977-02-01), Mueller
patent: 4284897 (1981-08-01), Sawamura et al.
patent: 4877965 (1989-10-01), Dandliker et al.
patent: 5022757 (1991-06-01), Modell
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5091653 (1992-02-01), Creager et al.
patent: 5095213 (1992-03-01), Strongin
patent: 5192980 (1993-03-01), Dixon et al.
patent: 5260578 (1993-11-01), Bliton et al.
patent: 5296700 (1994-03-01), Kumagai
patent: 5381224 (1995-01-01), Dixon et al.
patent: 5404247 (1995-04-01), Cobb et al.
patent: 5504336 (1996-04-01), Noguchi
patent: 5646411 (1997-07-01), Kain et al.
patent: 5713364 (1998-02-01), DeBaryshe et al.
Shoemaker et al., "An Ultrafast Laser Scanner Microscope for Digital Image Analysis", IEEE Transactions on Biomedical Engineering, vol. BME-29, No. 2, pp. 82-91 (Feb. 1982).

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