Fluorescence assay for measuring the rate of cholesterol...

Details Fluorescence assay for measuring the rate of cholesterol... Fluorescence assay for measuring the rate of cholesterol...

2007-09-18

2007-09-18

Gitomer, Ralph (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving cholesterol

Reexamination Certificate

active

10966628

ABSTRACT:
An improved method of obtaining fluorescence measurements which may be used as a measure of the CETP-catalyzed rate of transfer of a lipophilic non-polar fluorescent cholesteryl ester between lipoprotein particles is disclosed. The method may be used in assays for screening CETP inhibitors.

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patent: 2006/0040999 (2006-02-01), Ali et al.
Epps, D. et al. Method for Measuring the Activities of Cholesteryl Ester Transfer Protein. Chemistry and Physics of Lipids vol. 77, 51-63, 1995.
Bisgaier C. et al. Use of Fluorescent Cholesteryl Ester Microemulsions in Cholesteryl Ester Transfer Protein Assays. J of Lipid Research. vol. 34 1625-1634, 1993.
D.E. Epps et al., “Method for Measuring the Activities of Cholesteryl Ester Transfer Protein (Lipid Transfer Protein)”, Chemistry and Physics of Lipids, 77(1995), pp. 51-63.

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