Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2007-08-28
2007-08-28
Davis, Zinna N. (Department: 1625)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C546S153000, C546S176000
Reexamination Certificate
active
10819587
ABSTRACT:
The present invention provides a sensor and methods for determining kinase activity.
REFERENCES:
Chien-An, C. et al., “Biosensors of Protein Kinase Action: From In Vitro Assays to Living Cells”,Biochimica et Biophysica Acta,1697, pp. 39-51, 2004.
Chien-An, C. et al., “Design and Synthesis of a Fluorescent Reporter of Protein Kinase Activity”,J. Am. Chem. Soc.,124, pp. 3840-3841, 2002.
Higashi, H. et al., “Imaging of cAMP-Dependent Protein Kinase Activity in Living Neural Cells Using a Novel Fluorescent Substrate”,FEBS Letters,414, pp. 55-60, 1997.
Hofmann, R.M. et al., “Fluorescent Monitoring of Kinase Activity in Real Time: Development of a Robust Fluorescence-Based Assay for Abl Tyrosine Kinase Activity”,Bioorganic&Medicinal Chemistry Letters,11, pp. 3091-3094, 2001.
Kurokawa, K. et al., “A Pair of Fluorescent Resonance Energy Transfer-Based Probes for Tyrosine Phosphorylation of the CrkII Adaptor Protein in Vivo”,The Journal of Biological Chemistry,276, No. 33, pp. 31305-31310, 2001.
Lawrence, D., “Chemical Probes of Signal-Transducing Proteins”,Acc. Chem. Res.,36, pp. 401-409, 2003.
McIlroy, B. K. et al., “A Continuous Fluorescence Assay for Protein Kinase C”,Analytical Biochemistry,195, pp. 148-152, 1991.
Nagai, Y. et al., “A Fluorescent Indicator for Visualizing cAMP-Induced Phosphorylation in Vivo”,Nature America Inc.,18, pp. 313-316, 2000.
Post, P. et al., “A Genetically Engineered, Protein-Based Optical Biosensor of Myosin II Regulatory Light Chain Phosphorylation”,The Journal of Biological Chemistry,269 No. 17, pp. 12880-12887, 1994.
Sato, M. et al., “Fluorescent Indicators for Imaging Protein Phosphorylation in Single Living Cells”,Nature Biotechnology,20, pp. 287-294, 2002.
Shults, M.D. et al., “Versatile Fluorescence Probes of Protein Kinase Activity”,J. Am. Chem. Soc.,125, pp. 14284-14249, 2003.
Ting, A. Y. et al., “Genetically Encoded Fluorescent Reporters of Protein Tyrosine Kinase Activities in Living Cells”,PNAS,98, No. 26, pp. 15003-15008, 2001.
Violin, J.D. et al., “A Genetically Encoded Fluorescent Reporter Reveals Oscillatory Phosphorylation by Protein Kinase C”,The Journal of Cell Biology,161, No. 5, pp. 899-909, 2003.
Wright, D. E. et al., “Fluorometric Assay for Adenosine $3{circumflex over ())}{circumflex over (})}{\prime}$,$5{circumflex over ())}{circumflex over (})}{\prime}$-Cyclic Monophosphate-Dependent Protein Kinase and Phosphoprotein Phosphatase Activities”,Proceedings of the National Academy of Sciences of the United States of America,78, No. 10, pp. 6048-6050, 1981.
Yeh, R. et al., “Real Time Visualization of Protein Kinase Activity in Living Cells”,The Journal of Biological Chemistry,277 No. 13, pp. 11527-11532, 2002.
Zhang, J. et al., “Genetically Encoded Reporters of Protein Kinase A Activity Reveal Impact of Substrate Tethering”,PNAS,98, No. 26, pp. 14997-15002, 2001.
Shults M.D. et al., “Modular and Tunable Chemosensor Scafford for Divalent Zinc.”J. Am. Chem. Soc.,125, pp. 10591-10597, 2003.
International Preliminary Report On Patentability in corresponding PCT Application No. PCT/US2004/032733, date Apr. 20, 2005, 10 pgs.
Imperiali Barbara
Shults Melissa D.
Davis Zinna N.
Massachusetts Institute of Technology
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