Fluorescence-activated cell detector

Details Fluorescence-activated cell detector Fluorescence-activated cell detector

2009-02-19

2011-12-06

Evans, F. L. (Department: 2877)

Optics: measuring and testing

By shade or color

With color transmitting filter

C356S246000, C435S288700, C436S172000, C250S458100, C250S461200

Reexamination Certificate

active

08072603

ABSTRACT:
An apparatus for detecting particles of interest that are dispersed in a fluid mix, which typically includes other particles. The apparatus typically is associated with an interrogation platform arranged to operate in harmony with an opaque member having an orifice sized to promote single-file travel of the particles there-through. A currently preferred embodiment includes a light pipe configured to impinge stimulation-radiation substantially transverse to a direction of fluid flow through the opaque member. Particles of interest may be tagged using antibody-binding, fluorescing molecules. Stimulation radiation from the source causes the tagged particles to undergo a Stokes-shift emission of fluorescence. The resulting fluorescence is detected by the radiation detector and indicates passage of the particles of interest. One workable opaque member is advantageously included in a thin film assembly carried on a removable and disposable card that is adapted for reception in the interrogation platform.

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