Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1987-09-03
1990-12-18
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435 711, 43524024, 435243, 435813, 435819, C12P 2100, C12N 100, C12N 502
Patent
active
049786164
ABSTRACT:
A fluidized bed reactor and reaction process, particularly well-suited for culturing cells, for example, for tissue culture and fermentation processes, are described which involve the treatment of at least a portion of the fluid exiting the fluidized bed reactor in a side loop in a manner to alter its temperature or composition, e.g., oxygenation, with recirculation of this treated fluid to the reactor as a portion of the fluid causing bed fluidization.
REFERENCES:
patent: 2244902 (1941-06-01), Stich
patent: 2705136 (1955-03-01), Glitsch
patent: 2819049 (1958-01-01), Manning et al.
patent: 2856273 (1958-10-01), Beber et al.
patent: 3114677 (1961-07-01), Stich
patent: 3528889 (1970-09-01), Portno
patent: 3928143 (1975-12-01), Coughlin et al.
patent: 4001090 (1977-01-01), Kalina
patent: 4016044 (1977-04-01), Fresnel et al.
patent: 4032407 (1977-06-01), Scott et al.
patent: 4045184 (1977-08-01), Haralampiev et al.
patent: 4048018 (1977-09-01), Coughlin et al.
patent: 4127447 (1978-11-01), Griffith et al.
patent: 4138290 (1979-02-01), McMullen et al.
patent: 4153510 (1979-05-01), Messing et al.
patent: 4167450 (1979-09-01), Chesbro et al.
patent: 4189534 (1980-02-01), Levine et al.
patent: 4209591 (1980-06-01), Hendriks
patent: 4256839 (1981-03-01), Solomons et al.
patent: 4337315 (1982-06-01), Fukushima et al.
patent: 4397953 (1983-08-01), Guazzone et al.
patent: 4415668 (1983-11-01), Siegel
patent: 4519959 (1985-05-01), Takeuchi et al.
Aiba, Humphrey, Millis, "Biochemical Engineering" Academic Press, 1973, pp. 47-49, S. Cerevisiae.
V. Krumphanzl (editor), "Overproduction of Microbial Products", Academic Press, 1982, pp. 216-219.
S. Fazekas de St. Groth, "Automated Production of Monoclonal Antibodies in a Cytostat", Journal of Immunological Methods, vol. 57, pp. 121-136 (1983).
Boraston et al., "Growth and Oxygen Requirements of Antibody Producing Mouse hybridoma Cells in Suspension Culture", 5th General Meeting of E.S.A.C.T. Copenhagen, Denmark, 1982, Develop Biol. Standard, vol. 55, pp. 103-111.
Theoretical and Methodological Basis of Continuous Culture of Microorganisms, p. 232 (Malek & Fencl eds. Academic Press 1966).
J. S. M. Botterill, Fluid-Bed Heat Transfer, pp. 263-271, (Academic Press 1975).
Leva, "Press Drop and Power Requirements in a Stirred Fluidized Bed," A.I.Ch.E. Journal, vol. 6, pp. 688-692 (1960).
Lewis et al., "Entrainment from Fluidized Beds," Chemical Engineering Progress Symposium, vol. 58, pp. 65-78.
Williams & Smith, "Heat Transfer in a Mechanically Stirred, Gas-Solid Fluidized System," Chemical Engineering Progress Symposium Series, vol. 66, pp. 70-74.
Brekken et al., "Fluidization of Flour in a Stirred, Aerated Bed: Part I: General Fluidization Characteristics," Chemical Engineering Progress Symposium Series, vol. 66, pp. 81-90 (1980).
Brekken et al., "Fluidization of Flour in a Stirred Aerated Bed: Part II: Solids Mixing and Circulation," Chemical Engineering Progress Symposium Series, vol. 66, pp. 277-284 (1970).
Reed & Fenske, "Effects of Agitation on Gas Fluidization of Solids," Industrial and Engineering Chemistry, vol. 47, pp. 275-282 (1955).
Kozulin & Kulyamin, "Mixing of Powdered Materials in a Fluidized Bed," International Chemical Engineering, vol. 5, pp. 157-161 (1965).
Nazemi et al., "Heat Transfer in Fluidized Beds of Flour and Starch," A.I.Ch.E. Symposium Series, vol. 67, pp. 106-113.
Couderc et al., "Echanges Thermiques en Fluidisation Gazeuse," Chemical Engineering Science, vol. 21, pp. 533-539 (1966).
Botterill & Williams, "The Mechanism of Heat Transfer to Gas-Fluidized Beds," Trans. Instn. Chem. Engrs., vol. 41, pp. 217-230 (1963).
Feder & Tolbert (1983), Scientific American, 248:36-43.
Van Wezel et al., (1983) In Vitro, 19:259.
Feder et al., (1983) In Vitro, 12:260.
Karkare et al., (1985) Biotechnology, 3:247-251.
Karkare et al. (1983), "Immobilized Living Cell Systems for the Production of Fuels and Biochemicals", AIChE Diamond Jubilee Meeting, Oct. 31, 1983.
Dean and Venkatsubramian (1983), "Continuous Fermentation with Fluidized Slurries of Immobilized Microorganisms", American Chemical Society Annual Meeting, Aug. 30, 1983.
Karkare et al., (1984) "Continuous Production of Monoclonal Antibodies by Chemostatic and Immobilized Hybridoma Culture", American Chemical Society Annual Meeting, Aug. 27, 1984.
Dean, Jr. Robert C.
Grela Peter V.
Karkare Subhash B.
Runstadler, Jr. Peter W.
Beisner William H.
Verax Corporation
Wax Robert A.
LandOfFree
Fluidized cell cultivation process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fluidized cell cultivation process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluidized cell cultivation process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1425521