Fluid interface for bioprocessor systems

Chemistry: molecular biology and microbiology – Apparatus – Inoculator – streaker – or sampler

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S286500, C435S003000, C435S030000, C073S863710, C073S864000, C073S863810, C073S863820, C073S863850, C073S863860, C422S537000, C422S114000, C137S240000, C137S241000, C251S144000, C251S335300

Reexamination Certificate

active

07955843

ABSTRACT:
An apparatus and method for an aseptic fluidic interface between bioprocess systems is provided. The apparatus includes an inlet valve, adapted for automatic control, that is coupled to a biofluid source site. A sampling conduit extends from the inlet valve to an outlet valve. The outlet valve is adapted for automatic control and is coupled to a biofluid process site. A trap is at the sampling conduit. A waste valve, adapted for automatic control, is located at a waste conduit extending from the sampling conduit to a waste site. Also included is a wash fluid source that is coupled to at least one of the inlet or outlet valves. In the method, the sample is automatically directed to the biofluid process site by opening the outlet valve, and closing the waste valve. Also included is isolating the biofluid sites by closing the inlet and outlet valves, and opening the waste valve to drain biofluid from the trap to the waste site. Another step is cleaning the sampling conduit before sample collection by directing the wash fluid through at least one valve selected from the inlet and outlet valves, and subsequently through the waste valve to the waste site.

REFERENCES:
patent: 4167117 (1979-09-01), Stokley et al.
patent: 4785676 (1988-11-01), DeOca et al.
patent: 4830969 (1989-05-01), Holmes
patent: 4942770 (1990-07-01), Seifert et al.
patent: 4999307 (1991-03-01), Oakley
patent: 5075905 (1991-12-01), Rutherford
patent: 5296197 (1994-03-01), Newberg et al.
patent: 5372695 (1994-12-01), Demorest
patent: 5395588 (1995-03-01), North, Jr. et al.
patent: 5429728 (1995-07-01), Gordon
patent: 5460054 (1995-10-01), Tran
patent: 5482608 (1996-01-01), Keely et al.
patent: 5755155 (1998-05-01), Buesing
patent: 5771917 (1998-06-01), Carney et al.
patent: 5833826 (1998-11-01), Nordman
patent: 5902746 (1999-05-01), Colin et al.
patent: 5948998 (1999-09-01), Witte et al.
patent: 5985121 (1999-11-01), Wu et al.
patent: 6254060 (2001-07-01), Kennedy
patent: 6375855 (2002-04-01), Vassarotti
patent: 6418799 (2002-07-01), Pardue et al.
patent: RE37941 (2002-12-01), Guttman
patent: 6491804 (2002-12-01), Manz et al.
patent: 6491872 (2002-12-01), Wick
patent: 6537432 (2003-03-01), Schneider et al.
patent: 6637257 (2003-10-01), Sparks
patent: 6645758 (2003-11-01), Schnipelsky et al.
patent: 6689621 (2004-02-01), Merten et al.
patent: 7169599 (2007-01-01), Barringer, Jr.
patent: 2001/0005489 (2001-06-01), Jovanovich et al.
patent: 2002/0123154 (2002-09-01), Burshteyn et al.
patent: 2002/0170364 (2002-11-01), Gerard et al.
patent: 2004/0259241 (2004-12-01), Barringer, Jr.
patent: 0443320 (1991-08-01), None
patent: 0 566 645 (1994-10-01), None
patent: 0 607 234 (1995-05-01), None
patent: WO 93/06741 (1993-04-01), None
Arce, L, et al., “On-line Ion-exchange Preconcentration in a Flow Injection System Coupled to Capillary Electrophoresis for the Direct Determination of UV Absorbing Anions,”Analytica Chimica Acta, 390: 39-44 (1999).
Burgi, D. S. and Chien R., “Optimizatin in Sample Stacking for High-Performance Capillary Electrophoresis,”Analytical Chemistry, 63(18): 2042-2047 (1991).
Bleha, M, et al., “Role of Convection in Dialysis Desalination of Protein Mixtures by Microporous Charged Neosepta Membranes,” Membrane: 21(2): 144-152 (1996).
Chen, H and Fang, Z, “Combination of Flow Injection with Capillary Electrophoresis. Part 3. On-line Sorption Column Preconcentration Capillary Electrophoresis System,”Analytica Chimica Acta: 355: 135-143 (1997).
Chien, R. and Burgi, D. S., “Sample Stacking of an Extremely Large Injection Volume in High-Performance Capillary Eletrophoresis,”Analytical Chemistry, 64(9): 1046-1050 (1992).
Jiang, Z., et al., “Separation of Pyridazinone Derivatives Using Pressurized Gradient Capillary Electrochromatography,”J. Microcolumn Separations: 13(5) 191-196 (2001).
Jin, H., et al., “Purification and Renaturation of Recombinant Human Lymphotoxin (Tumour Necrosis Factor Beta) Expressed inEscherichia colias Inclusion Bodies,”J. Chem. Tech. Biotechnol., 59: 67-72 (1994).
Kaul, R. and Mattiasson, B, “Secondary Purification,”Bioseparation, 3: 1-26 (1992).
Kuban, P., et al., “New Interface for Coupling Flow-injection and Capillary Electrophoresis,”Analytica Chimica Acta, 337: 117-124 (1997).
Lacoste, B., et al., “Study of an Aerobic Concentrated Culture Reactor Coupled to Separation by Crossflow Micro- or Ultra-filtration Through Inorganic Membranes. Initial Approach to a Depollution Application,”Revue des Sciences de l'Eau, 6(4): 363-380 (1993).
Masi, C. G., “Choosing Automation for Fast Liquid Sample Handling,”Drug Discovery&Development, Jan. issue: 36-41 (2003).
Seifert, G. K. E. and Matteau, P. P., “An Automatic Aseptic Bioreactor Sampling System,”Biotechnology and Bioengineering, 32: 923-926 (1988).
Shihabi, Z., “Stacking in Capillary Zone Electrophoresis,”Journal of Chromatography A, 902: 107-117 (2000).
Sinacola, J. R. and Robinson, A.S., “Rapid Refolding and Polishing of Single-chain Antibodies fromEscherichia coliInclusion Bodies,”Protein Expression&Purification, 26: 301-308 (2002).
Tishchenko, G., et al., “Separation of Specific Immunoglobulin. 1. Desalination Using a Membrane System,”Bioseparation, 5: 19-25 (1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fluid interface for bioprocessor systems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluid interface for bioprocessor systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluid interface for bioprocessor systems will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2634254

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.