Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-02-14
1997-06-03
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
422 55, 422 58, 422 61, 422101, 435 721, 435259, 4352871, 4352872, 4352882, 4352884, 4352885, 4352887, 435810, 436164, 436165, 436514, 436518, 436524, 436527, 436805, 436806, 436807, 436809, 436824, G01N 33543, G01N 33558
Patent
active
056353588
ABSTRACT:
Disclosed are devices and methods for analyzing a fluid cell containing sample. The devices are composed of a solid substrate, microfabricated to define at least one sample inlet port and a mesoscale flow system. The mesoscale flow system includes a sample flow channel, extending from the inlet port, and a cell handling region for treating cells disposed in fluid communication with the flow channel. The devices may further include a component for inducing flow of cells in the sample through the flow system. In one embodiment, the cell-handling region may include a cell lysis component to enable the lysis of cells in the sample, prior to, e.g., the detection of an intracellular component in the cell sample. In another embodiment, the cell handling region may have a cell capture region, with binding sites which reversibly bind to a specific population of cells in the cell sample, to permit the isolation of the specific cell population from the sample. The devices can be utilized in a wide range of automated sensitive and rapid tests for the analysis of a fluid cell containing sample.
REFERENCES:
patent: 4233029 (1980-11-01), Columbus
patent: 4302313 (1981-11-01), Columbus
patent: 4350768 (1982-09-01), Tihon et al.
patent: 4618476 (1986-10-01), Columbus
patent: 4676274 (1987-06-01), Brown
patent: 4790640 (1988-12-01), Nason
patent: 4906439 (1990-03-01), Grenner
patent: 4908112 (1990-03-01), Pace
patent: 4911782 (1990-03-01), Brown
patent: 4999283 (1991-03-01), Zavos et al.
patent: 5304487 (1994-04-01), Wilding et al.
Anderson, Nature, 335:379 (1992).
Angell, et al., Scientific American, 248:44-55 (1983).
Appenzeller, Science, 254:1300-1342 (1991).
Barany, Proc. Natl. Acad. Sci, 88:189-192 (1991).
Brown, "Development of a Stopped-Flow Cytometer," NSF Grant No. ISI 87-60730.
Brunette, Exper. Cell Res., 167:203-217 (1986).
Brunette, Exper. Cell Res., 164:11-26 (1986).
Columbus et al., Clin. Chem., 33:1531-1537 (1987).
DeLuca et al., Arch. Biochem. Biophys., 255:285-292 (1983).
Dessy, Chemometrics and Intelligent Laboratory Systems, 8:311 (1990), Abstract.
Esashi et al., "Integrated Flow Control Systems Fabricated on a Silicon Wafer," Proceedings, Electrochemical Society Conference, HI (18-23 Oct., 1987), Electrochemical Society, Pennington, NJ, pp. 31-38B, 1987.
Fromherz et al., Biochimica et Biophysica Acta, 1062:103-107 (1991).
Goin et al., Clin. Chem., 32:1655-1659 (1986).
Haller in: Solid Phase Biochemistry, W.H. Scouten, Ed., John Wiley, New York, pp. 535-597 (1983).
Hanazato et al., IEEE Transactions Electron. Devices; ED33:47-51 (1986).
Hoopman, "Microchanneled Structures," Applied Technology Laboratory, 3M Center, St. Paul, MN 55144-1000.
Howe et al., IEEE Transactions Electron Devices, ED33:499-506 (1986).
Hung et al, Med. & Biol. Engng., 9:237-245 (1971).
Jonsson, Methods in Enzymology, 137:381-389 (1988).
Kennedy et al., Clin. Chem. Acta., 70:1-31 (1976).
Kenny et al., Appl. Phys. Lett., 58:100-102 (1991).
Kikuchi et al., "Microchannels Made on Silicon Wafer for Measurement of Flow Properties of Blood Cells," Biorheology, 26:1055 (1989), Abstract.
Kittilsland et al., Journal de Physique, 49 (C4):641-644 (1988).
Kittilsland et al., Sensors and Activators, A21-A23:904-907 (1990).
Kricka et al., "Liquid Transport in Micron and Submicron Channels," SPIE, 1167:159-168 (1989).
Kricka et al., Clin Chem., 26:741-744 (1980).
LaCelle, Blood Cells, 12:179-189 (1989).
Mandenius et al., Anal. Biochem., 137:106-114 (1984).
Mandenius et al., Anal. Biochem., 170:68-72 (1988).
Mandenius et al., Methods in Enzymology, 137:388-394 (1988).
Manz et al., Trends in Anal. Chem., 10:144-149 (1991).
Masuda et al. Proc. IEEE/IAS Meeting, pp. 1549-1553 (1987).
McCartney et al., Cancer Res., 41:3046-3051 (1981).
Moghissi et al., Am. J. Obstet. Gynecol., 114:405-(1972).
Nakamura, Immunochemical Assays and Biosensor Technology for the 1990's, American Society of Microbiology, Washington, D.C., pp. 205-215 (1992).
Nakamura et al., Anal. Chem., 63:268-272 (1991).
Parce et al., Science, 24:243-247 (1989).
Rosenberg et al., Clin. Chem., 30:1462-1466 (1984).
Rosenberg et al., Clin. Chem., 31:1444-1448 (1985).
Sankolli et al., J. Imun. Methods, 104:191-194 (1987).
Sato, et al., Sensors and Actuators, A21-A23:948-951 (1990).
Shoji, et al., Sensors and Actuators, 15:101-107 (1988).
Stange et al., Biomaterials, 9:3-6 (1988).
Van Lintel, Sensors and Actuators, 15:153-167 (1988).
Wallis et al., J. Amer. Ceramic Soc., 53;563-567 (1970).
Washizu et al., Proceedings IEEE/IAS Meeting, pp. 1735-1740 (1988).
Weissman et al., Am. Inst. Chem. Eng. J., 17:25-30 (1971).
Zemel et al. in : Fundamentals and Applications of Chemical Sensors, D. Schuetzle and R. Hammerle, Eds., ACS Symposium Series 309, Washington, D.C., 1986, p. 2.
Biotrack, Ciba Corning, May, 1989.
Wilding, Advanced Hospital Technology Laboratory, Oct., 1990 pp. 38-42.
Roche, On-Track.TM., Sep., 1988.
Pfahler et al., "Liquid Transport in Micron and Submicron Channels," Sensors and Actuators, A21-A23:431-434 (1990).
Tracey, et al., "Microfabricated Microhaemorheometer," IEEE International Conference on Solid-State Sensors and Actuators, pp. 82-84 (1991).
Washizu, et al., "Handling of Biological Cells Using Fluid Integrated Circuit," IEEE Industry Applications Society Annual Meeting, 2:1735-1740 (1988).
Kricka Larry J.
Wilding Peter
Zemel Jay N.
Chin Christopher L.
Trustees of the University of Pennsylvania
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