Fluctuation analysis for enhanced particle detection

Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation

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2504581, 2504591, 2504612, 356318, 356417, 364554, 364819, G01N 2164

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046766405

ABSTRACT:
An improvement is disclosed in a method for measuring intensity fluctuations of an electromagnetic signal of wavelength between about 350 nm to 1200 nm from a liquid medium. The improvement comprises autocorrelating the intensity of the signal over a non-zero interval the duration of which is short compared to the mean duration of the fluctuations. The method has particular applciations in the diagnostic area, particularly where such fluctuations are a result of the presence of fluroscent particles in a liquid medium. Methods are also disclosed for determining an analyte in a sample suspected of containing such analyte.

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Betty et al., Anal. Chem., V. 48, N. 13, Nov. 1976, p. 1899.
Kam et al., Rev. Sci. Instrum., vol. 46, No. 3, Mar. 1975, p. 269.

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