Chemical apparatus and process disinfecting – deodorizing – preser – Process disinfecting – preserving – deodorizing – or sterilizing – Using disinfecting or sterilizing substance
Patent
1996-03-11
2000-06-13
McKane, Elizabeth
Chemical apparatus and process disinfecting, deodorizing, preser
Process disinfecting, preserving, deodorizing, or sterilizing
Using disinfecting or sterilizing substance
435 2, 4351721, 4351736, 4352852, 935 85, C12N 1300
Patent
active
06074605&
ABSTRACT:
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cell, characterized by an optionally automated, continuous-flow, self-contained electroporation system which allows withdrawal of blood from a patient, separation of red blood cells, encapsulation of a biologically-active substances in the cells, and optional recombination of blood plasma and the modified red blood cells thereby producing blood with modified biological characteristics. The present invention is particularly suited for use to encapsulate allosteric effectors of hemoglobin, thereby reducing the affinity of erythrocytes for oxygen and improving the release of oxygen from erythrocytes in tissues.
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Acker Jesse L.
Meserol Peter M.
Prodell Rita C.
Entremed, Inc.
McKane Elizabeth
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