Flow cytometry

Details Flow cytometry Flow cytometry

1987-01-20

1989-04-04

McGraw, Vincent P.

Optics: measuring and testing

With plural diverse test or art

324 714, 356246, G01N 2105, G01N 2708

Patent

active

048181030

ABSTRACT:
A flow cytometer has an aperture in which an inlet chamber and/or an outlet chamber have predetermined geometric relationships with respect to the aperture for decreasing electronic edge effects and increasing the sensitivity of electronic particle volume measurements. In one embodiment, the aperture is triangular and is formed by assembling a plurality of truncated pyramids with their truncated surfaces defining aperture walls. At least one of the elements forming the aperture walls is either part of a lens systems or a transparent cover plate so that simultaneous optical and electronic cell volume measurements can be performed. In one embodiment, a piezoelectric transducer is provided to sonically clear any aperture clogging.

REFERENCES:
patent: 3497690 (1970-02-01), Wheeless, Jr. et al.
patent: 3628140 (1971-12-01), Hogg et al.
patent: 3710933 (1973-01-01), Fulwyler et al.
patent: 3739258 (1973-06-01), Karuhn et al.
patent: 3810010 (1974-05-01), Reinhard
patent: 3924951 (1975-12-01), Dittrich
patent: 4673288 (1987-06-01), Thomas et al.
"Uniform Lateral Orientation, Caused by Flow Forces of Flat Particles in Flow-Through Systems", the Jour. of Histochemistry & Cytochemistry, vol. 25, #7, pp. 774-780, 1977.
"Combined Optical Telectronic Analysis of Cells with the AMAC Transducers"-R. A. Thomas et al.

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