Flow cytometric method and kit for metal-induced sensitivity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S811000

Reexamination Certificate

active

08071325

ABSTRACT:
This invention provides methods for determining metal-induced sensitivity of a subject and kits for affecting the same. Specifically, the invention provides methods for using immune cell proliferation resulting from exposure to test metals as a method for determining metal-induced sensitivity in subjects.

REFERENCES:
patent: 2003/0228635 (2003-12-01), Hu et al.
patent: 2006/0263761 (2006-11-01), Fontenot et al.
McCabe et al. Low Level Lead Exposure In Vitro Stimulates the Proliferation and Expansion of Alloantigen-Reactive CD4High T-Cells; Toxicology and Applied Pharmacology, vol. 177 (2001) pp. 219-231.
Nygaard et al. Blood and Spleen Lymphocytes As Targets for Immunotoxic Effects in the Rat—A Comparison; Toxicology, vol. 174 (2002) pp. 153-161.
Fontenot et al. Target Organ Localization of Memory CD4+ T Cells in Patients With Chronic Beryllium Disease; The Journal of Clinical Investigation, vol. 110, No. 10 (2002) pp. 1473-1482.
Fontenot et al. CD28 Costimulation Independence of Target Organ Versus Circulating Memory Antigen-Specific CD4+ T Cells; The Journal of Clinical Investigation, vol. 112, No. 5 (2003) pp. 776-784.
Shapiro, H.M. Parameters and Probes; Practical Flow Cytometry, Chapter 7.12, (2003) pp. 369-381.
Jabbour et al. A Flow Cytometric Assay for Beryllium Sensitization: Screening and Mechanistic Applications; Beryllium Research Symposium: Basic Mechanisms and Human Health, Jun. 25-25, 2002. downloaded from: http://www.ornl.gov/sci/techresources/meetings/beryllium/session1.shtml.
Amicosante M, et al. Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69.. Hum Immunol 2001;62:686-693.
Appay V, et al. Characterization of CD4(β) CTLs ex vivo. J Immunol 2002;168:5954-5958.
Barna BP et al. Clinical application fo Beryllium Lymphocyte Proliferation Testing. Clin Diagn Lab Immunol 2003;10:990-994.
Bartell SM, et al. Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. Risk Anal 2000;20:87-99.
Bernard S, et al. Analysis of cell kinetics using a cell division marker. Mathematical modeling of experimental data. Biophys J 2003;84:3414-3424.
Bill JR, et al. Beryllium presentation to CD4β T cells is dependent on a single amino acid residue of the MHC class II beta-chain. J Immunol 2005;175:7029-7037.
Deubner D, et al. Beryllium sensitization, chronic beryllium disease, and exposures at a beryllium mining and extraction facility.. Appl Occup Environ Hyg 2001;16:579-592.
Deubner DC, et al. Variability, predictive value, and uses of the beryllium blood lymphocyte proliferation test (BLPT): Preliminary analysis of the ongoing workforce survey. Appl Occup Environ Hyg 2001;16:521-526.
Farris GM, et al. Detection of Beryllium sensitivity using a flow cytometric lymphocyte proliferation test: The Immuno-Be-LPT. Toxicology 2000;143:125-140.
Fontenot AP, et al. Frequency of beryllium-specific, central memory CD4β T cells in blood determines proliferative response. J Clin Invest 2005;115:2886-2893.
Givan AL, et al. A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens.. J Immunol Methods 1999;230:99-112.
Henneberger PK, et alBeryllium sensitization and disease among long-term and short-term workers in a beryllium ceramics plant. Int Arch Occup Environ Health 2001;74:167-176.
Henneberger PK, et al. Industries in the United States with airborne beryllium exposure and estimates of the numbers of current workers potentially exposed. J Occup Environ Hyg 2004;1:648-659.
Janeway CA Jr, et al. CD4β T cells: Specificityand function. Immunol Rev1988; 101:39-80.
Kreiss K, et al. Chronic beryllium disease—From the workplace to cellular immunology, molecular immunogenetics, and back. Clin Immunol Immunopathol 1994;71:123-129.
Kreiss K, et al. Screening blood test identifies subclinical beryllium disease. J Occup Med 1989;31:603-608.
Lehnert NM, et al. Inhibition of normal human lung fibroblast growth by beryllium.. Toxicology 2001;160:119-127.
Lyons AB, Hasbold J, Hodgkin PD. Flow cytometric analysis of cell division history using dilution of carboxyfluorescein diacetate succinimidyl ester, a stably integrated fluorescent probe. Methods Cell Biol 2001;63:375-398.
Lyons AB. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods2000;243:147-154.
Lyons AB. Divided we stand: Tracking cell proliferation with carbox-yfluorescein diacetate succinimidyl ester. Immunol Cell Biol 1999;77:509-515.
Maier LA. Beryllium health effects in the era of the beryllium lymphocyte proliferation test. Appl Occup Environ Hyg 2001;16:514-520.
Maier LA. Clinical approach to chronic beryllium disease and other non pneumoconiotic interstitial lung diseases. J Thorac Imaging 2002;17:273-284.
Maier LA. Genetic and exposure risks for chronic beryllium disease. Clin Chest Med 2002;23:827-839.
McCanlies EC, et alHLA-DPB1 and chronic beryllium disease: A HuGE review.. Am J Epidemiol 2003; 157:388-398.
Milovanova T, et al.Flow Cytometric Test for Beryllium Sensitivity. Cytometry part B Clinical Cytometry 2004;60:23-30.
Newman LS. Significance of the blood beryllium lymphocyte proliferation test. Environ Health Perspect 1996;104 (Suppl 5):953-956.
Nikolaeva N, et al. Differentiation of human alloreactive CD4β and Cd8β T cells invitro. Transplantation 2004;78:815-824.
Rossman MD, et alProliferative response of bronchoalveolar lymphocytes to beryllium. A test for chronic beryllium disease.. Ann Intern Med 1988;108:687-693.
Rossman MD. Chronic beryllium disease: Diagnosis and management. Environ Health Perspect 1996;104 (Suppl 5):945-947.
Rossman MD. Chronic beryllium disease: A hypersensitivity disorder. Appl Occup Environ Hyg 2001;16:615-618.
Saltini C, et al. Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells. N. Engl J Med 1989;320:1103-1109.
Sawyer RT, et al. Beryllium-induced TNF-{alpha} production by CD4β T Cells is mediated by HLA-DP.. Am J Respir Cell Mol Biol 2004;31:122-130.
Spitzer RL, et al. Quantification of agreement in psychiatric diagnosis. A new approach. Arch Gen Psychiatry 1967;17:83-87.
Stange AW, et al. Beryllium sensitization and chronic beryllium disease at a former nuclear weapons facility. Appl Occup Environ Hyg 2001;16:405-417.
Stokes RF, et al. Blood cell proliferation response to beryllium: Analysis by receiver-operating characteristics.. J Occup Med1991;33:23-28.
Viet SM, et al. Chronic beryllium disease and eryllium sensitization at Rocky Flats: A case-control study. Am Ind yg Assoc J 2000;61:244-254.
Viola A, et al. Lanzavecchia Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering. J Exp Med 1997;186:1775-1779.
Wang Z, et al. Beryllium sensitivity is linked to HLA-DP genotype.. Toxicology 2001;165:27-38.
Wells AD, et al. Following the fate of individual T cells throughout activation and Clonal Expansion. J Clinical Investigation 1997;100:3173-3183.
Wells AD, et al. T cell effector function and energy avoidance are quantitatively linked to cell division. J Immunol 2000;165:2432-2443.
Weston A, et al. Racial differences in prevalence of a supratypic HLA-genetic marker immaterialto pre-employment testing for susceptibility to chronic beryllium disease. Am J Ind Med 2002;41:457-465.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Flow cytometric method and kit for metal-induced sensitivity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Flow cytometric method and kit for metal-induced sensitivity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Flow cytometric method and kit for metal-induced sensitivity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4294775

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.