Flow cytometric analysis of histamine receptors

Details Flow cytometric analysis of histamine receptors Flow cytometric analysis of histamine receptors

1981-11-09

1984-10-02

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 29, 435810, 436501, 436503, 436506, 436507, G01N 3348, G01N 3350, G01N 2164

Patent

active

044748760

ABSTRACT:
A method for analyzing cells to determine whether they have substantial numbers of H1 and H2 histamine receptors. Also an assay kit and a composition for conducting such analyses. The assays involve fluorescent polymeric molecules to which a plurality, preferably from about 30 to about 100, of histamine or histamine blocker molecules are attached. Procedures for optimizing several variables which are essential to effective and reliable determinations.

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patent: 4220450 (1980-09-01), Maggio
patent: 4256834 (1981-03-01), Zuk et al.
Osband et al., "Biochemical Analysis of Specific Histamine H1 and H2 Receptors on Lymphocytes", Chem. Absts., vol. 95, No. 7, p. 306 (1981), Absts. No. 57537w.
Matthyssen et al., "Binding of Histamine and other Ligand Conjugated Macromolecules to Lymphocytes", Chem. Absts., vol. 83, No. 7, p. 332 (1975), Absts. No. 56622k.
Rocklin, "Modulation of Cellular-Immune Responses in Vivo and in Vitro by Histamine Receptor-Bearing Lymphocytes", J. Clin. Invest., vol. 57, No. 4 (1976), pp. 1051-1058.

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