FLK-1 is a receptor for vascular endothelial growth factor

Details FLK-1 is a receptor for vascular endothelial growth factor FLK-1 is a receptor for vascular endothelial growth factor

1995-05-22

1998-12-22

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 932, 4353201, A61K 4800, C12N 500, C12N 1500

Patent

active

058519998

ABSTRACT:
The present invention relates to the use of ligands for the FLK-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cells and the identification of vascular endothelial growth factor (VEGF) as the high affinity ligand of Flk-1. These results indicate a major role for Flk-1 in the signaling system during vasculogenesis and angiogenesis. Engineering of host cells that express Flk-1 and the uses of expressed Flk-1 to evaluate and screen for drugs and analogs of VEGF involved in Flk-1 modulation by either agonist or antagonist activities is described. The invention also relates to the use of FLK-1 ligands, including VEGF agonists and antagonists, in the treatment of disorders, including cancer, by modulating vasculogenesis and angiogenesis.

REFERENCES:
Ueno et al (1991) Science 252: 844-848.
Ueno et al (1992) J. Biol. Chem. 267: 1470-1476.

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