Flexibly labeling peptides

Details Flexibly labeling peptides Flexibly labeling peptides

2007-08-24

2010-11-30

Cordero Garcia, Marcela M (Department: 1654)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C530S324000, C530S326000, C530S328000, C530S329000, C530S330000, C530S331000

Reexamination Certificate

active

07842280

ABSTRACT:
A solid phase peptide synthesis method for synthesizing a peptidyl contrast agent is disclosed. In one example, the method includes synthesizing an amino-chelator loaded resin, coupling of the amino-chelator loaded resin to the C-terminus and/or backbone of a peptide, cleaving the amino-chelator-peptide from a resin, and chelating a lanthanide metal to the amino-chelator-peptide.

REFERENCES:
patent: 2006/0039859 (2006-02-01), Sharma et al.
Smith et al. Radiochemical investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH2: an in vitro / in vivo assessment of the targeting ability of this new radiopharmaceutical for PC-3 human prostate cancer cells. Nuclear Medicine and Biology. 2003. vol. 30, pp. 101-109.
Yoo et al. A facile synthesis of alpha-amino-DOTA as a versatile molecular imaging probe. Tetrahedron Letters. 2006. vol. 47, pp. 7327-7330.
De Leon-Rodriguez et al. The Synthesis and Chelation Chemistry of DOTA-Peptide Conjugates. Feb. 2008. vol. 19, No. 2, pp. 391-402.

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