Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1998-01-28
2000-04-04
Warzel, Mark L.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
525 88, 525 93, 524505, 428 354, 428522, 428524, C08L 2706, B32B 2730, B65D 3002
Patent
active
060462744
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to a flexible composition comprising a vinyl chloride polymer and a block copolymer, to a use of this composition for the manufacture of an article and to an article comprising this composition.
TECHNOLOGY REVIEW
Flexible compositions based on vinyl chloride polymer have been used for a long time in the most diverse industrial applications. Applications may be mentioned, for example, in the building, automobile, decorating and medical accessory fields.
In the last field, it is particularly advantageous to have available materials which exhibit good compatibility and complete harmlessness with respect to biological tissues and medicinal principles with which these materials can come into contact.
The excellent properties of flexible poly(vinyl chloride), such as its high transparency, and the wide range in the degree of flexibility which may be made available with this material make it a very widely used constituent in many medical applications.
In order to improve the biocompatibility of polymeric materials such as poly(vinyl chloride), a number of processes have been developed.
Some of these processes resort to surface treatments, which treatments are physical or chemical in nature. For example, Patent Application EP-A-0,093,094 describes a process according to which the surface of the polymer to be treated is made more hydrophilic after a number of cycles in which it is brought into contact with solutions followed by evaporation of the solvent. This type of process, in which solvents are handled, is complicated and expensive to implement industrially.
Other types of processes resort to the incorporation of modifying agents in the formulation of the composition. Thus, Patent Application JP-A-01,181,873 describes a mixture of flexible poly(vinyl chloride) and of a block copolymer obtained by reaction of a polycarboxylic polyester with a polysiloxane polyol or polysiloxane polyamine. Similarly, an article (Tsai et al., Asaio Journal (1994), Vol. 40, No. 3, pp. M619-M624) describes a poly-.epsilon.-caprolactone/polydimethylsiloxane/poly-.epsilon.-caprolacto ne block copolymer incorporated in a vinyl chloride polymer flexible composition.
However, while this last type of surface modification improves the compatibility of poly(vinyl chloride) with biological tissues and blood in particular, it does not guarantee perfect neutrality with respect to these. In particular, the adsorption of some components, such as proteins or blood cells, remains too high. This causes a decrease in their true concentration in the medium when the latter is brought into contact with the polymeric surface. Now, in many applications, it is essential that the concentration of certain components, including proteins in particular, in solutions or in tissues remains constant with time. It is also important that the additives employed in these formulations exhibit a minimum desorption when they are brought into contact with a biological tissue.
SUMMARY OF THE INVENTION
The subject of the invention is therefore a vinyl chloride polymer flexible composition which makes it possible to bring this composition into contact with media comprising organic macromolecules, more particularly proteins or peptides, without substantial adsorption of the latter at the surface of the composition nor significant desorption of its consituents.
The invention consequently relates to a flexible composition comprising a vinyl chloride polymer and a block copolymer which is characterized in that the block copolymer is chosen from copolymers comprising a poly(ethylene oxide) block and a block of a polymer which is miscible with the vinyl chloride polymer, other than the latter itself.
DETAILED DESCRIPTION OF THE INVENTION
Vinyl chloride polymer is understood to denote any vinyl chloride homopolymer, any vinyl chloride copolymer, and mixtures of these homo- and/or copolymers. Homopolymers have given very good results.
The composition is said to be flexible when it additionally comprises a substantial am
REFERENCES:
patent: 3312753 (1967-04-01), Bailey et al.
patent: 3689531 (1972-09-01), Critchfield et al.
patent: 3949015 (1976-04-01), Laverty et al.
Grandjean Dominique
Hoyweghen Danny Van
Hruska Zdenek
Wautier Henri
Solvay ( Societe Anonyme)
Warzel Mark L.
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