Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Reexamination Certificate
2005-05-24
2005-05-24
Travers, Russell (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
C424S443000, C424S444000, C424S445000, C424S446000, C424S401000, C424S405000, C424S070220, C424S070240, C424S070310, C424S730000, C424S070230, C514S390000, C514S939000, C514S940000, C514S941000, C514S943000
Reexamination Certificate
active
06896897
ABSTRACT:
A flexible applicator for applying an oil-in-water emulsion comprises: (1) an allantoin-containing oil-in-water emulsion; and (2) a flexible element that adsorbs or absorbs the emulsion such that the emulsion is applied to the skin of a patient on whom the flexible applicator is placed. The allantoin-containing emulsion, containing allantoin and an emulsifier, has improved stability coming from the adjustment of the pH to a range of 3.0 to 6.0; preferably, the pH is in the range of 4.5 to about 5.8. The lower pH preserves the stability of the allantoin and the functionality of the emulsifier system is maintained. The emulsifier system can be a nonionic emulsifier or an anionic emulsifier plus beeswax. The acid used to adjust the pH can be an organic acid or an inorganic acid. The emulsion can further comprise other ingredients such as herbal extracts, chelating agents, preservatives, emollients, solvents, and fragrance. The flexible element can be in the form of a bandage or wipe, and can be formed of a material such as cotton, cellulose, nylon, rayon, a non-woven fabric, or a plastic polymer.
REFERENCES:
patent: 3830824 (1974-08-01), Margraf
patent: 3830825 (1974-08-01), Margraf
patent: 3830908 (1974-08-01), Klippel et al.
patent: 3856805 (1974-12-01), Margraf
patent: 3930000 (1975-12-01), Margraf
patent: 3932627 (1976-01-01), Margraf
patent: 3954989 (1976-05-01), Mecca
patent: 4170229 (1979-10-01), Olson
patent: 4278664 (1981-07-01), Van Cleave
patent: 4374766 (1983-02-01), Puchalski et al.
patent: 4478853 (1984-10-01), Chaussee
patent: 4507279 (1985-03-01), Okuyama et al.
patent: 4670263 (1987-06-01), Noorlander
patent: 4707354 (1987-11-01), Garlen et al.
patent: 4708813 (1987-11-01), Snyder
patent: 4806262 (1989-02-01), Snyder
patent: 4880621 (1989-11-01), Grollier et al.
patent: 4933117 (1990-06-01), Grollier et al.
patent: 4981845 (1991-01-01), Pereira
patent: 5112886 (1992-05-01), Phalangas
patent: 5122533 (1992-06-01), Bar-On et al.
patent: 5176916 (1993-01-01), Yamanaka et al.
patent: 5221533 (1993-06-01), Perlman
patent: 5455033 (1995-10-01), Silverman et al.
patent: 5476664 (1995-12-01), Robinson et al.
patent: 5512200 (1996-04-01), Garcia
patent: 5567427 (1996-10-01), Papadakis
patent: 5578312 (1996-11-01), Parrinello
patent: 5616347 (1997-04-01), Alliger et al.
patent: 5658559 (1997-08-01), Smith
patent: 5661170 (1997-08-01), Chodosh
patent: 5709847 (1998-01-01), Bissett et al.
patent: 5736128 (1998-04-01), Chaudhuri et al.
patent: 5824666 (1998-10-01), Deckner et al.
patent: 5827870 (1998-10-01), Chodosh
patent: 5830483 (1998-11-01), Seidel et al.
patent: 5849310 (1998-12-01), Trinh et al.
patent: 5863548 (1999-01-01), Elder
patent: 5871754 (1999-02-01), Briggs et al.
patent: 5871762 (1999-02-01), Venkitaraman et al.
patent: 5876736 (1999-03-01), Cohen et al.
patent: 5885581 (1999-03-01), Massand
patent: 5914116 (1999-06-01), Suares et al.
patent: 5932228 (1999-08-01), Hall et al.
patent: 5952373 (1999-09-01), Lanzendörfer et al.
patent: 5958436 (1999-09-01), Hahn et al.
patent: 5968528 (1999-10-01), Deckner et al.
patent: 6001377 (1999-12-01), SaNogueira, Jr. et al.
patent: 6060061 (2000-05-01), Breton et al.
patent: 6080393 (2000-06-01), Liu et al.
patent: 6086903 (2000-07-01), Trinh et al.
patent: 6120782 (2000-09-01), Mansouri
patent: 6174533 (2001-01-01), SaNogueira, Jr. et al.
patent: 6281236 (2001-08-01), Farber
patent: 6306915 (2001-10-01), Murata
patent: 6337065 (2002-01-01), Jacobson et al.
patent: 0242553 (1987-10-01), None
patent: 0380157 (1990-08-01), None
patent: 1346544 (1974-02-01), None
patent: 358140013 (1983-08-01), None
patent: 404208219 (1992-07-01), None
patent: WO 9009779 (1990-09-01), None
Registry Copyright 2002 ACS, RN 99-76-3 and RN 94-13-3.*
Product information insert for Alphosyl Cream and Alphosyl Lotion, G.D. Searle (South Africa), Apr. 24, 1975.
Product information insert for Clearsil Mediated Facial Cleanser, Procter & Gamble (South Afrida), Jan. 31, 199.
Product information insert for Arola Rosebaum Ointment, Supramed Limited, Jan. 12, 1986.
Abstract of a publication, M. Cajkovac et al., “Influence of Emulsoid Vehicle on the Release and Activity of Allantoin,”Pharmacie47 :39-43 (1992) (abstract only).
Abstract of a publication, M. Maragakis et al., “Possibilities of Scar Treatment After Thoracic Surgery,”Drugs Under Exp.&Clin. Res.21:199-206 (1995) (abstract only).
Product information insert for Alphosyl, undated.
Abstract of a publication, G. Stinco et al., “Seborrheic Dermatitis Treated with Furalglucitole Cream,”Dermatol. Clin.18:78-81 (1998) (abstract only).
Abstract of a publication, G.H. Willital & H. Heine, “Efficiency of Contractubex® Gel in the Treatment of Fresh Scars After Thoracic Surgery in Children and Adolescents,”Int. J. Clin Pharmacol. Res.14:193-202 (1994) (abstract only).
H.W. Margraf & T.H. Covey, Jr., “A Trial of Silver-Zinc-Allantoinate in the Treatment of Leg Ulcers,”Arch. Surg.12:699-704 (1977).
Remington: The Science and Practice of Pharmacy (19thEd. 1995, Mack Publishing Co., Easton, Pennsylvania), pp. 639-640, 1380.
D. Hoffmann, “The Complete Illustrated Herbal,” (Barnes and Noble, 1996), pp. 63, 104.
F.R. Greenbaum, “The Story of Allantoin,”Am. J. Pharm.112:205-216 (1940).
M.A. Lesser, “Allantoin,”Drug Cosmet. Ind.42:451-456, 469 (1938).
I.I. Lubowe & S.B. Mecca, “Allantoin and Aluminum Derivatives in Dermatological Applications,g”Drug Cosmet. Ind.84:36, 37, 117 (1959).
S.B. Mecca, “Allantoin anda the Newer Aluminum Allantoinates,”Proc. Scient. Sect. Toilet Goods Assoc.No. 31: 1-6 (1959).
S.B. Mecca, “The Function and Applicability of the Allantoins,”Proc. Scient. Sect. Toilet Goods Assoc.No. 39: 7-15 (1963).
P. LeVan, “The Use of Silicones in Dermatology,”Calif. Med.81:210-213 (1954).
R. Cahen & A. Pessonnier, “Etude Pharmacologique de L'Allantoïnatede Dihydroxyaluminium et de L'Allantoïnate de Chlorhydroxyaluminium. 1.—Toxicité,”Ann. Pharm. Franc.20: 623-636 (1962) (in French), discloses the physical and chemical properties and the toxicity of dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate. The compounds were observed to have no toxicity.
R. Cahen & J.-F. Clement, “Etude Pharmacologique de L'Allantoïnate de Dihydroxyaluminium et de L'Allantoïnat de Chlorhydroxyaluminium. II.—Etude de l'Activité Gastrique,”Ann. Pharm. Franc.20: 693-703 (1962) (in French), discloses the activity of dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate on gastri activity. The compounds were found to have acid-neutralizing and buffering activity and to diminish gastric acidity.
R. Cahen & A. Pessonnier, “Etude Pharmacologique de L'Allanoïnate de Dihydroxyaluminium et de L'Allantoïnate de Chlorhydroxyaluminium. III—Effet Anti-ulcéreux,”Ann. Pharm. Franc.20: 704-713 (1962) (in French), discloses the anti-ulcer activity of the compounds dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate. The compounds were found to have anti-ulcer activity in rats and guinea pigs comparable to compounds such as aluminum hydrate and bismuch subnitrate.
R. Cahen & A. Pessonnier, “Etude Pharmacologique de L'Allantoïnate de Dihydroxyaluminum et de L'Allatoïnate de Chlorhydroxyaluminium. IV.—Effet sur l'Ulcère Mėdicamenteux Expérimental,”Ann. Pharm. Franc.21: 215-222 (1963) (in French), discloses the effect of the compounds dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate on ulcers produced in the rat by administration of phenylbutazone or reserpine. The compounds were found to have activity against such ulcers.
C. Debray et al., “Etude de Dèrivés Allantoïniques de l'Aluminium dans la Thérapeutique des Affections Gastro-duodénales,”Presse Méd.70: 2643-2644
Alwyn Company, Inc.
Hogan & Hartson LLP
Sharareh Shahnam
Travers Russell
LandOfFree
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