Flea protease proteins, nucleic acid molecules, and uses thereof

Details Flea protease proteins, nucleic acid molecules, and uses thereof Flea protease proteins, nucleic acid molecules, and uses thereof

1995-06-07

1998-01-27

Housel, James C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4242651, 514830, 530113, C12N 948, C07K 140, A61K 3900

Patent

active

057121435

ABSTRACT:
The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

REFERENCES:
patent: 4800159 (1989-01-01), Mullis et al.
patent: 5356622 (1994-10-01), Heath et al.
Azad et al.,Am. J. Trop. Med. Hyg., 1987, 37:629-635.
Billingsley,Annu. Rev. Entomol., 1990, 35:219-248.
Borovsky et al.,FASEB J., 1990, 4:3015-3020.
Borovsky , Arch. Insect Biochem. Physiol., 1988, 7:187-210.
Casu et al.,Insect Mol. Biol., 1994, 3(4):201-211.
Casu et al.,Insect Mol. Biol., 1994, 3(3):159-170.
Cherney et al.,Am. J. Trop. Med., 1939, 19:327-332.
Chinzei et al., Med. Vet. Entomol., 1987, 1:409-416.
Elvin et al., Mol. Gen. Genet., 1993, 240:132-139.
Halliwell, J. Immunol., 1973, 110:422-30.
Halliwell et al., J. Allerg. Clin. Immunol., 1978, 62:236-242.
Halliwell et al., Vet. Immunol. Immunopathol., 1985., 8:215-223.
Hatfield, Med. Vet. Entomol., 1988, 2:331-338.
Hatfield, Med. Vet. Entomol., 1988, 2:339-345.
Houk et al., pp. 135-146, 1986, Archives of Insect Biochemistry and Physiology, vol. 3.
Johnston et al., Int. J. Parasitol., 1986, 16(1):27-34.
Kalhok et al., Insect Mol. Biol., 1993, 2(2):71-79.
Kay et al., Am. J. Trop. Med. Hyg., 1994, 50(6) Supp.:87-96.
Kemp et al., Internat. J. Parasitol., 1986, 16, 115-120.
Kwochka, Vet. Clin. North Am., 1987, 17:1235-1262.
Law et al., Annu. Rev. Biochem., 1992, 61:87-111.
McFarlane, "Nutrition and Digestive Organs", in Fundamentals of Insect Physiology, M.S. Blum, ed., John Wiley and Sons, New York, New York, 1985, pp. 59-89.
Muller et al., EMBO J., 1993, 12(7):2891-2900.
Nesbitt et al., J. Am. Vet. Med. Assoc., 1978, 173:282-288.
Opdebeeck et al., Immunol., 1988, 63:363-367.
Opdebeeck et al., Parasite Immunol., 1988, 10:405-410.
Opdebeeck et al., Immunol., 1989, 67:388.
Otieno et al., Insect Sci. Applic., 1984, 5(4):297-302.
Ramos et al., Insect Mol. Biol.,1993, 1(3):149-163.
Rand et al., Proc. Natl. Acad. Sci. (USA), 1989, 86:9657-9661.
Ribiero, Ann. Rev. Entomol., 1987, 32:463-478.
Sandeman et al., Int. J. Parasitol., 1990, 20(8):1019-1023.
Schlein et al., Physiolog. Entomol., 1976, 1:55-59.
Soulsby, in Helminths, Arthropods and Protozoa of Domesticated Animals, 7th ed., 1982, Lea and Febiger, eds., Philadelphia, PA, pp. 378-384.
Vaughn et al., J. Med. Entomol., 1988, 25:472-474.
Wikel, Vet. Parasitol., 1984, 14:321-329.
Wikel, Vet. Parasitol., 1988, 29:235-264.
Willadsen et al., J. Immunol., 1989, 143:1346-1351.
Wong et al., Immunol., 1989, 66, 149-155.
Young et al., 1963, Exp. Parasitol., 13:155-166.
Eldridge, J.H. et al., "New Advances in Vaccine Delivery Systems", Seminars in Hematology, vol. 30, No. 4, Suppl. 4 (Oct.1993), pp. 16-25.
Cuypers et al., "The Primary Structure of Leucine Aminopeptidase From the Bovine Eye Lens." J. Biol. Chem. 257(12):7077-7085, 1982.
Matsushima et al., "Structural and Immunological Evidence for the Identity of Probyl Aminopeptidase with Leucyl Aminopeptidase" Biochem. Biophys. Res. Comm. 178(3):1459-1464, 1991.

Affiliated with

Also associated with

Rating

Flea protease proteins, nucleic acid molecules, and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Flea protease proteins, nucleic acid molecules, and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Flea protease proteins, nucleic acid molecules, and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-341183