Flavonoids-rich tissues from Neomarica gracilis and...

Chemistry: molecular biology and microbiology – Plant cell or cell line – per se ; composition thereof;...

Reexamination Certificate

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C435S420000, C435S430000, C435S431000, C424S773000

Reexamination Certificate

active

07824914

ABSTRACT:
The present invention provides an in vitro flavonoid-rich rhizome tissue ofNeomarica gracilis, which is obtained from a tissue culture preparation of anN. gracilistissue capable of proliferating, such as a root, a leaf, a basal portion of a leaf, and/or a rhizome. The in vitro flavonoid-rich rhizome tissue ofN. graciliscontains tectorigenin, which is distinctively different from the naturally grown rhizome ofN. graciliswhich contains no tectorigenin. The present invention further provides a method for cultivating the in vitro flavonoid-rich rhizome tissue, a method for extracting the tectorigenin from the flavonoid-rich rhizome tissue, and quantitative methods for determining the amount of tectorigenin in the in vitro flavonoid-rich rhizome tissue.

REFERENCES:
patent: 2004/0176310 (2004-09-01), Wuttke et al.
Chu, T. “The Rhizome Tissue Multiplication, Tectorigenin and Total Flavonoid Analysis ofNeomarica gracilisand Belamcanda chinensis by Liquid Culture,” Thesis for Master of Science, Tatung University, Jul. 2006.
Dodds et al. “Experiments in Plant Tissue Culture,” Cambridge University Press, 3rdEdition, 1995, pp. 198, 205-207 and 240.
Zhong et al. “Effects of plant growth regulators on cell growth and ginsenoside saponin production by suspension cultures of Panax quinquefolium,” Journal of Biotechnology 45 (1996) 227-234.
Tomoyoshi Akashi et al, “Isoflavonoid production by adventitious-root cultures ofIris germanica(Iridaceae)”, Plant Biotechnology vol. 22(3), 2005, pp. 207-215.
Adbel Nasser B. Singab, “Flavonoids fromIris spuria(Zeal) Cultivated in Egypt”, Arch Pharm Res vol. 27, No. 10, 1023-1028, 2004.
Min-Jian Qinet al., “A New Isoflavonoid fromBelamcanda chinensis(L.) DC.”, Journal of Integrative Plant Biology (Formerly Acta Botanica Sinica), vol. 47, No. 11, 2005, pp. 1404-1408.
Tin-Hui Chu; The Rhizome Tissue Multiplacation, Tectorigenin and Total Flavonoid . . . ; Thesis for Master of Science Department of Bioengineering Tatung University; Jul. 2006.
Abdel Nasser B. Singab; Flavonoids fromIris spuria(Zeal) Cultivated in Egypt; Arch Pharm Res; 2004; vol. 27, No. 10; pp. 1023-1028.
Min-Jian Qin; A New Isoflavonoid fromBelamcanda chinensis(L.) DC.; Journal of Integrative Plant Biology; 2005; vol. 47; pp. 1404-1408.

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