Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-09-29
1999-12-21
Stockton, Laura L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549400, 549402, 549403, A61K 3135, C07D31128, C07D31130, C07D31132
Patent
active
060049987
ABSTRACT:
Certain flavonoids, notably derivatives of flavone, chrysin and apigenin, together with dimers thereof such as amentoflavone, have been found to possess anxiolytic properties (i.e., anxiety reducing properties) without exhibiting a sedative effect. Novel compounds and pharmaceutical formulations are also described.
REFERENCES:
patent: 3903266 (1975-09-01), Robbins
patent: 4241069 (1980-12-01), Buckler et al.
Chen et al. (CA 107:236283), 1987.
Guidugli et al. (CA 102:5497), 1985.
J.H. Medina et al; Chrysin (5,7-Di-Oh-Flavone), A Naturally-Occuring Ligand For Benzodiazepine Receptors, With Anticonvulsant Properties, Biochemical Pharmacology, 40 No. 10, pp. 2227-2231 (1990).
M. Nielsen et al; High Affinity Of The Naturally-Occurring Biflavonoid, Amentoflavon, To Brain Benzodiazepine Receptors In Vitro, Biochemical Phamacology, 37, No. 17, pp. 3285-3287 (1988).
B.K. Chakravarthy et al; Isolation of Amentoflavone from Selaginella rupestris and its Pharmacological activity on Central Nervous System, Smooth Muscles and Isolated Frog Heart Preparations; Planta Medica 43, pp. 64-70 (1981).
K. Hayashi et al; Mechanism of Action of the Antiherpesvirus Biflavone Ginkgetin, Antimicrobial Agents and Chemotherapy, 36 No. 9, pp. 1890-1893 (1992).
R.K. Goel et al; Mechanism of anti-ulcerogenic effect of amentoflavone, Indian J. Med. Res 88, pp. 192-196 (1988).
G. Spedding et al; Inhibition of reverse transcriptases by flavonoids, Antiviral Research 12, pp. 99-110 (1989).
M.R. Cholbi et al; Inhibitory effects of phenolic compounds on CCI.sub.4 -induced microsomal lipid peroxidation, Experientia 47, pp. 195-199 (1991).
K.H. Shin et al; Sedative Action of Spinosin, Arch. Pharm. Res. 1 (1), pp. 7-11 (1978).
Batchelor et al. (CA 102:24352), 1985.
Edwards et al. (CA 91:13471), 1979.
He et al. (CA 111:7098), 1989.
Batchelor et al. (CA 92:128727), 1980.
Sasaki et al. (CA 72:26333) 1970.
Kinoshita et al. (CA 114:101428) 1991.
Singh et al. (CA 113:114871) 1990.
He et al. (CA 113:6095) 1990.
Thakar et al. (CA 100:121000) 1984.
Cutroneo et al. (CA 77:13948) 1972.
Lakshmi et al. (CA 77:5287) 1972.
Covello et al. (CA 74:99795) 1971.
Prakash et al. (CA 114:101416) 1991.
Hoshino et al. (CA 98:71744) 1983.
Reddy et al. (CA 94:83887) 1981.
Letcher (CA 113:23428) 1990.
Sangwan et al. (CA 101:23175) 1984.
Looker et al. (CA 100:85455) 1984.
Metzner et al. (CA 98:83243) 1983.
Covello et al. (CA 84:112062) 1976.
Reichel et al. (CA 83:96949) 1975.
Dhar et al. (CA 83:42478) 1975.
Pownall (CA 81:48936) 1974.
Cassels Bruce Kennedy
Dajas Federico Jose
Medina Jorge Horacio
Paladini Alejandro Constantino
Silveira Rodolfo Horacio
Stockton Laura L.
University of Strathclyde
LandOfFree
Flavonoid and biflavonoid derivatives, their pharmaceutical comp does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Flavonoid and biflavonoid derivatives, their pharmaceutical comp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Flavonoid and biflavonoid derivatives, their pharmaceutical comp will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-505680