Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-09
1995-09-26
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549 21, C07D31122, C07D33908, A61K 3135, A61K 31385
Patent
active
054535182
ABSTRACT:
A compound of the general formula: ##STR1## wherein X represents --CO--, --COO--, --CONH--, --CON(CH.sub.3)--, --CH.sub.2 NH--, --CH.sub.2 N(CH.sub.3)--, --CH.sub.2 NHCO--, --CH.sub.2 N(CH.sub.3)CO--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, or --CH.sub.2 SO.sub.2 --; n represents an integer from 1 to 4; and B represents one of the following groups: ##STR2## wherein R.sub.1 represents a lower alkyl (C.sub.1 -C.sub.4) group; R.sub.2 represents a hydrogen atom or a lower alkyl (C.sub.1 -C.sub.4) group; R.sub.3 represents a hydrogen atom or OR.sub.4 group wherein R.sub.4 represents a lower alkyl (C.sub.1 -C.sub.4) group; p represents an integer from 1 to 3; and Y represents a valence bond (Y1), or one of the following groups: ##STR3## wherein R.sub.2 is as above defined as well as the enantiomers, diastereomers, N-oxides, prodrugs, metabolites, prodrugs of metabolites, and pharmaceutically acceptable salts of these compounds. The compounds are long-lasting antispasmodic therapeutic agents and are particularly useful for the treatment of lower urinary tract disorders.
REFERENCES:
patent: 2921070 (1960-01-01), Da Re
patent: 3277094 (1966-10-01), Werner
patent: 3350411 (1967-10-01), Da Re
patent: 3810896 (1974-05-01), Witte et al.
patent: 4089969 (1978-05-01), Muchowski et al.
patent: 4495198 (1985-01-01), Wu
patent: 4539318 (1985-09-01), Baldwin et al.
patent: 4668804 (1987-05-01), Wu
patent: 4668805 (1987-05-01), Wu
patent: 4684651 (1987-08-01), Kikumoto et al.
patent: 4797498 (1989-01-01), Albrecht et al.
patent: 4940711 (1990-07-01), Nardi et al.
patent: 5091182 (1992-02-01), Ong et al.
Atassi et al., Eur. J. Med. Chem., 20:393-402 (1985).
Augstein et al., J. Med. Chem., 8:356-367 (1965).
Bagli, J. Med. Chem., 19:876-882 (1976).
Bonte et al., Eur. J. Med. Chem. 25:361-368 (1990).
Carroll et al., J. of Med. Chem., 19(9):1111-1119(1976).
Cunico et al., Org. Chem., 48:2780-2782(1983).
Da Re, Ann. Chim. pp. 506-513 (1962).
Da Re et al., Eur. J. Med. Chem., 13:387-388 (1987).
Da Re et al., J. Med. Chem., 2(3):263-269 (1960).
Engel et al., J. Med. Chem., 33:2976-2981 (1990).
Frishman et al., Cardiovascular Pharmacotherapy II, 72(2):427-440 (1988).
Garcia--Sainz et al., Biochemical and Biophysical Research Communications, 186(2):760-767(1992).
Gartside et al., European Journal of Pharmacolgy, 191:391-400 (1900).
Grewal et al., J. Pharmac. Exp. Therap., 160(2):268-276 (1968).
Hamon et al., Annals New York Academy of Sciences, pp. 114-131 (1990).
Hartig et al., Drug Delivery Res., 26(3):215-224 (1992).
Laubie et al., Arzheim-Forsch, 19:1820-1826 (1969).
Leclerc et al., Arzheim-Forsch Drug. Res., 35:1357-1367 (1985).
Mielke et al., Curr. Therap. Res., 15:(6):324-326 (1973).
Mull et al, J. Med. Chem., 8:332-338 (1965).
Overberger et al., J.A.C.S., 71:2661-2666 (1949).
Perez et al., Molecular Pharmacology, 40:876-883 (1991).
Ratouis et al., J. Med. Chem., 8:271-273 (1965).
Ratouis et al., J. Med. Chem., 8:104-107 (1965).
Romero et al., Annual Reports in Medical Chemistry, 27(3):21-30 (1992).
Saari et al., J. Med. Chem., 33:97-101 (1990),
Silvestrini et el., Arzheim-Forsch./Drug. Res., 32:668-673 (1982).
Traber et al., TIPS, 8:432-437 (1987).
Uneyama et al., Bull. Chem. Soc. Jpn., 58:2361-2365 (1985).
Valenti et al., Boll. Chim. Farm., 114:294-300 (1975).
Vizi et al., Medicinal Research Reviews, 6:431-449 (1986).
Wu et al., J. Med. Chem., 35:3519-3525 (1992).
Zifa et al., Pharmacological Reviews, 44(3):401-458 (1992).
Drugs of the Future, 6:346-347 (1981).
Chemical Abstracts 55:5534a (1959).
Chemical Abstracts 59:2832b (1963).
Chemical Abstracts 63:11589h (1965).
Chemical Abstracts 66:3769s (1967).
Chemical Abstracts 66:85664e (1967).
Chemical Abstracts 67:64435m (1967).
Chemical Abstracts 76:14577z (1972).
Chemical Abstracts 78:584606 (1973).
Chemical Abstracts 98:107161d (1983).
Chemical Abstracts 83:131584c (1975).
Chemical Abstracts 84:59400u (1976).
Chemical Abstracts 100:103390q (1984).
Chemical Abstracts 104:109686v (1985).
Chemical Abstracts 104:19499g (1985).
Chemical Abstracts 105:78821z (1986).
Chemical Abstracts 107:236661v (1987).
Chemical Abstracts 108:15674v (1988).
Chemical Abstracts 108:37647r (1988).
Chemical Abstracts 108:150298r (1988).
Chemical Abstracts 109: 128816g (1988).
Chemical Abstracts 110:135063h (1989).
Chemical Abstracts 111:153607p (1989).
Chemical Abstracts 112:216577x (1990).
Chemical Abstracts 113:109332n (1990).
Chemical Abstracts 116:262282c (1992),
Chemical Abstracts 59:10006g (1963).
Chemical Abstracts 81:20780e (1974).
Derwent Abstract, C93-164399 (1993).
Guarneri et al., Neurourol. Urodyn., 11:340-41 (1992).
Farina et al., Biochem. Pharm., 31:1887-1892 (1982).
Farina et al., Biochem. Pharm., 35:209-215 (1986).
Derwent Abstract #84:143670/23, 1984.
Derwent Abstract #84:143671/23, 1984.
Derwent Abstract #86:064962/10, 1986.
Derwent Abstract #86:322242/49, 1986.
Derwent Abstract #92:064865/08, 1992.
Derwent Abstract #92:077567/10, 1992.
Derwent Abstract #87:104761/15, 1987.
Derwent Abstract #90:019323/03, 1989.
Derwent Abstract #91:055570/08, 1991.
Derwent Abstract #91:153784/21, 1991.
Guarneri Luciano
Leonardi Amedeo
Motta Gianni
Riva Carlo
Ivy C. Warren
M. Mach D. Margaret
Recordati S.A. Chemical and Pharmaceutical Company
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