Flavone-8-acetic acid and interleukin-2 in a method of treating

Details Flavone-8-acetic acid and interleukin-2 in a method of treating Flavone-8-acetic acid and interleukin-2 in a method of treating

1988-04-15

1992-03-17

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514456, A61K 3135, A61K 4505

Patent

active

050967070

ABSTRACT:
A treatment regimen for cancers having cells which are susceptible to an interleukin-2 activated natural killer cell mediated anti-cancer effect, the method comprises administering to a patient an effective amount of a combination of interleukin 2 and flavone-8-acetic acid. The treatment regimen is particularly effective in the treatment of renal carcinoma. Synergistic pharmaceutical compositions are also provided. effective in the treatment of renal carcinoma. Synergistic pharmaceutical compositions are also provided.

REFERENCES:
Chemical Abstracts 99:175594t (1983).
Rosenberg et al., The New England J of Med., Apr. 9, 1987, vol. 316, No. 15, pp. 889-897.
Immunobiology of Natural Killer Cells, vol. 2, pp. 2-8 (1986).
The Journal of Investigative Dermatology, vol. 83, pp. 137s-140s (1984).
The Journal of Immunology, vol. 139, No. 1, pp. 279-284 (1987).
Immunology, vol. 59, p. 251-259 (1986).

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