Flavivirus recombinant poxvirus vaccine

Details Flavivirus recombinant poxvirus vaccine Flavivirus recombinant poxvirus vaccine

1991-06-13

1996-05-07

Sidberry, Hazel F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4241841, 4242021, 4242041, 4242051, 4242181, 4242321, 435 693, 4351723, 4353201, 530350, 530826, 536 2372, 514 2, A61K 39285, A61K 39295, C07K 1418, C12N 701

Patent

active

055143750

ABSTRACT:
What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from flavivirus, such as Japanese encephalitis virus, yellow fever virus and Dengue virus. In a preferred embodiment, the recombinant poxvirus generates an extracellular particle containing flavivirus E and M proteins capable of inducing neutralizing antibodies, hemagglutination-inhibiting antibodies and protective immunity against flavivirus infection. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.

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