Flavivirus inhibition by sultams and related compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S359000

Reexamination Certificate

active

08003674

ABSTRACT:
Disclosed herein are compounds, compositions and methods for treating or ameliorating flavivirus infections. This is particularly important because the present disclosure provides methods for treating flavivirus infections for which there is no effective vaccine.

REFERENCES:
patent: 6258831 (2001-07-01), Camden
patent: 2006/0025416 (2006-02-01), Phadke et al.
patent: WO 2006/060774 (2006-06-01), None
Paula “New Drug target for hepatitis C and other Flaviviridae viruses,” Infectious Disorders-Drug Targets, 2009, vol. 9, pp. 133-147.
Buckwood et al. “Bovine viral diarrhea virus as a surrogate model of hepatitis C virus for the evaluation of antiviral agents,” Antiviral Research, 2003, vol. 60 pp. 1-15.
Linden and Goerdeler, “Reaktion von Iminodithiazolen mit Sulfenen zu S-Fliedrigen Sultamen,”Tetrahedron Letters20:1729-1732, 1977.
Barklis et al., “Sultam Thiourea Inhibition of West Nile Virus,”Antimicrob. Agents Chemother. 51:2642-2645, 2007.

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