Flavin adenine dinucleotide-labeled conjugates for use in specif

Details Flavin adenine dinucleotide-labeled conjugates for use in specif Flavin adenine dinucleotide-labeled conjugates for use in specif

1978-10-12

1980-07-22

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

536 26, 424177, 536 27, C07C10352, C07G 700, A61K 3700, C07H 1916

Patent

active

042138930

ABSTRACT:
Labeled conjugates of the formula: ##STR1## wherein Riboflavin--Phos).sub.2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide (FAD), n=2 through 6, and --CO)L is a specifically bindable ligand, or a binding analog thereof, and is preferably an iodothyronine such as thyroxine, bound through an amide bond; and intermediates produced in the synthesis of such FAD-labeled conjugates. The FAD-labeled conjugates are useful as labeled conjugates in specific binding assays for determining the ligand or a specific binding partner thereto in liquid media such as serum.

REFERENCES:
Hoard, D., and Ott, D., JACS, 87, 1785 (1965).
Guilford, H., et al., Chemica Scripta, 2, 165 (1972).
Trayer, I., et al., Biochem. J.,139, 609 (1974).
Asakura, H., et al., J. Radiat. Res., 15, 19 (1974).
Zomlicka, J., and Owens, J., J. Org. Chem., 42, 517 (1977).

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