Flavin adenine dinucleotide analogue inhibitors of monoamine oxi

Details Flavin adenine dinucleotide analogue inhibitors of monoamine oxi Flavin adenine dinucleotide analogue inhibitors of monoamine oxi

1995-05-24

1998-05-26

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2625, A61K 3170, C07H 19207

Patent

active

057564795

ABSTRACT:
The present invention provides an inhibitor of monoamine oxidase comprising a modified synthetic flavin adenine dinucleotide compound. Also provided is a method of inhibiting monoamine oxidase enzymatic activity in a cell, comprising the step of contacting said cell with a pharmacologically effective dose of a modified synthetic flavin adenine dinucleotide compound. Further provided is a method of treating a brain pathophysiological state in an individual, comprising administering a therapeutically effective dose of a modified synthetic flavin adenine dinucleotide compound to said individual.

REFERENCES:
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Weyler et al., "Catalytically Active Monoamine Oxidase Type A from Human Liver Expressed in Saccharomyces cerevisiae Contains Covalent FAD," Biochem. Biophys. Res. Comm., 173(3), 1205-1211 (1990).
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Barber et al., "Anti-Flavin Antibodies," Biochemical Journal, 242, 89-95 (1987).
T. W. Stone (I), "Adenine Dinucleotide Effects in the Nervous System," in Physiology and Pharmacology of Adenosine Derivatives, Daly et al. eds., Raven Press, New York, NY, 1983, pp. 237-244.
Tat'yanenko et al., Tyramine Oxidase Studied Using Structural Analogs of Flavine Adenine Dinucleotide, Mol. Biol. (Moscow), 8(6), 871-878 (1974); Chem. Abstr., 82(17), p.185, Abstr. No. 108082k (1975); only Abstract supplied.
McCormick et al., "Coenzyme Specificity of D-Amino Acid Oxidase for the Adenylate Moiety of FAD," Biochim. Biophys. Acta, 89, 4476-452 (1964).
Wierenga et al., "Prediction of the Occurrence of the ADP-binding .beta..alpha..beta.-fold in Protiens, Using an Amino Acid Sequence Fingerprint," J. Mol. Biol., 187, 101-107 (1986).
Abell et al., "Molecular and Functional Properties of the Monoamine Oxidases," Heterocycles, 39(2), 933-955 (1994).
T. W. Stone (II), "Actions of Adenine Dinucleotides on the Vas Deferens, Guinea-Pig Taenia Caeci and Bladder," European J. of Pharmacology, 75(2-3), 93-102 (1981).

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