Flavanone derivatives

Details Flavanone derivatives Flavanone derivatives

1985-08-28

1990-06-26

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514100, 549403, 549220, 536 8, 536 132, 536 133, 536 136, 536 138, 536 166, A61K 3135, C07D31128

Patent

active

049372572

ABSTRACT:
New flavanone derivatives of the formula I ##STR1## wherein Ar.sup.1 and Ar.sup.2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO.sub.2 and/or substituted by a methylenedioxy group, and the alkyl, alkoxy and acyl groups each have 1-7 C atoms, but wherein the HO group is only in the 6-position if at least one of the radicals Ar.sup.1 and Ar.sup.2 is substituted phenyl, and the phosphoric acid esters thereof and the salts of these compounds display antiallergic effects. Salts of the I-phosphoric acid esters with aminoglycoside antibiotics are outstandingly stable and possess advantageous kinetics of liberation.

REFERENCES:
patent: 3678044 (1972-07-01), Adams
patent: 4241069 (1980-12-01), Buckler et al.
Batterham et al., C.A., 61, 2620f (1964)-Abstract of Australian J. Chem., 17, 428 (1964).
Siekel et al., C.A. 57 12418(f), vol. 61 (1962).
Shah et al., C.A. 61 3008(f), vol. 61 (1964).
Martin Negwer, Organisch-Chemische Arzneimittel und Ihre Synonyma, pp. 699 and 940, 1978.

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