Flavanol and cysteamine conjugates

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S356000, C549S381000, C549S396000, C514S183000, C514S228800, C514S229500, C514S230500, C514S230800

Reexamination Certificate

active

06936726

ABSTRACT:
The present invention refers to new products generated by the conjugation of flavanols with molecules that contain the thiol group. New molecules are obtained from polyphenolic plant extracts rich in oligomeric and polymeric procyanidines and prodelfinidins. In this way, new products are generated with antioxidant properties for application as protective agents for the organism against disorders such as cancer, cardiovascular diseases and premature aging. The invention also refers to obtaining these new agents from waste material generated by the agroalimentary industry. Since these waste materials are highly complex mixtures a simple and effective method is described to isolate and purify these, based on the physico-chemical characteristics of the new molecules.

REFERENCES:
patent: 01025726 (1989-01-01), None
Abstract of “Journal of Agricultural Food Chemistry, Oct. 2001, 49(10): 4627-37”.
Abstract of “Organic Letters, Nov. 25, 2004, 6(24): 4583-6”.
Torres et al., DN 135:3708587 abstract of New Flavanol Derivatives from Grape Byproducts, Sep. 13, 2001, Journal o Agricultural and Food Chemistry (2001), 49(10), 4627-4634.
Patent Abstract of Japan of JP 01025726 Dated Jan. 27, 1989.
Torres, J.L., et al. “New flavanol derivatives from grape (Vitis vinifera) by products . . . ”Journal of Agricultural and Food Chemistry-American Chemical Society (2001) vol. 49, No. 10, pp. 4627-4634.
Torres, J.L., et al. “Chromatographic Characterization of Proanthocyanidins after Thiolysis with Cysteamine”Chromatographia(2001) vol. 54, No. 7/8, pp. 523-526.
Wirth, C., et al. “Pharmacologically active Procyanidines from the bark of Uncaria tomentosa”Phytomedicine(1997)vol. 4, No. 3, pp. 265-266.
Facino, R.M., et al. “Free Radicals Scavenging Action and Anti-enzyme Activities . . . ”Arzneim-Forsch(1994) vol. 44, No. 5, pp. 592-601.

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