Liquid purification or separation – Processes – Chromatography
Patent
1984-11-26
1986-05-27
Adee, John
Liquid purification or separation
Processes
Chromatography
2101982, B01D 1508
Patent
active
045914427
ABSTRACT:
A flash chromatography apparatus and method for rapid, moderate-resolution separation of organic compounds. A solvent reservoir is pressurized with a gas, forcing solvent under pressure through tubing into and through a sorbent-packed chromatography column. More than one solvent reservoir may be provided to permit mixed-solvent elution. Alternatively, instead of pressurizing the solvent with compressed air, one or more metering pumps may be used to deliver solvent to the column. The method includes introducing a sample to be eluted into the top of a flash chromatography column, beginning elution by introducing an elution solvent under pressure into the top of the column, the elution solvent comprising a first solvent and a second solvent in a ratio from 0:1 to 1:0, modifying the elution solvent by varying the ratio of the first solvent to the second solvent, and continuing elution with the modified elution solvent.
REFERENCES:
patent: 3935097 (1976-01-01), Roof
patent: 4295422 (1981-10-01), Still
patent: 4310420 (1982-01-01), Konishi et al.
patent: 4379751 (1983-04-01), Yoritomi et al.
Application of Forced Flow Liquid Chromatography to the Determination of Iron by Seymour et al. Analytical Chemistry, vol. 43, No. 13, Nov. 1971, pp. 1734-1736.
Adee John
Baran Robert J.
Nelson Research & Development Co.
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