Flanking peptides of calcitonin and processes for their manufact

Details Flanking peptides of calcitonin and processes for their manufact Flanking peptides of calcitonin and processes for their manufact

1989-08-23

1994-10-11

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

530324, 530402, C07K 700, C07K 106, A61K 3730

Patent

active

053548434

ABSTRACT:
Peptides of formula I ##STR1## in which R is hydrogen or acetyl and X is an amino acid sequence of formula -Ser-Leu-Asp-Ser-Pro-Arg-Ser- (Ia) or of formula -Arg-Ile-Ile-Ala-Gln- (Ib), and salts of such compounds, can be used for the treatment of diseases involving bone degeneration.

REFERENCES:
G. Komos et al., J. Biol. Chem. 361, 14386-14391 (1986).
Burns et al., FASEB J. (295) #4949 (1988).
Burn et al. Clin. Res. 36(1) 1504 (1988).
Howard et al. Abstracts, Conference on Calcium Regulating Hormones Joint Mtg. Sep. 9-14, 1989, Montreal, Canada (1989) #571.

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