Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-03-20
2007-03-20
Navarro, Mark (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S069100, C424S234100
Reexamination Certificate
active
10424721
ABSTRACT:
Purified and isolated nucleic acid molecules are provided which encode a FlaC flagellin protein of a strain ofCampylobacter,particularlyC. jejuni,or a fragment or an analog of the FlaC flagellin protein. The nucleic acid molecules may be used to produce proteins free of contaminants derived from bacteria normally containing the FlaA or FlaB proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules, proteins encoded thereby and antibodies raised against the proteins, may be used in the diagnosis of infection.
REFERENCES:
patent: 5516630 (1996-05-01), Ticehurst et al.
patent: 5618533 (1997-04-01), Flavell et al.
patent: 5679564 (1997-10-01), Pace et al.
patent: 6087105 (2000-07-01), Chan et al.
patent: 6211159 (2001-04-01), Chan et al.
patent: 6585980 (2003-07-01), Chan et al.
patent: 92/13102 (1992-08-01), None
patent: 94/12641 (1994-06-01), None
Khawaja, Rubina et al, Current Microbiology, vol. 24, pp. 213-221, 1992, Cloning and sequence analysis of the flagellin gene ofCampylobacter jejuniTGH9011.
Chan et al, Gene, 1995, pp. 25-31, Cloning and transcription regulation ofthe ferric uptake regulatory gene ofCampylobacter jejuniTGH9011.
Harrington, Clare S. et al, Journal of Clinical Microbiology, vol. 35(9), pp. 2386-2392, Sep. 1997, Evidence for recombination in the flagellin locus ofCampylobacter jejuni: Impilications for the flagellin gen typing scheme.
Komoriya, Kaoru et al, Molecular Microbiology, Vo. 34(4), pp. 767-779, 1999, Flagellar proteins and type III exported virulence factors are the predominant proteins secreted into th culture media ofSalmonella typhimurium.
Song, YC et al, Molecular Microbiology, vol. 53(2), apges 541-553, 2004, FlaC, a protein ofCampylobacter jejuniTGH9011 (ATCC43431) secreted throguh the flagellar apparatus, binds epithelial cells and influences cell invasion.
Kim, Y et al, Journal of Bacteriology, Jul. 2000, vol. 182(13), pp. 3693-3704, Analysis of the Polar flagellar gene system ofVibrio parahaemolyticus.
McGee, K et al, Journal of Bacteriology, Sep. 1996, vol. 178(9), pp. 5188-5198, Sep. 1996, Indentification and characterization of additional flagellin genes fromVibrio anguillarum.
Fan, F et al, The Journal of Biological Chemistry, vol. 271(50), pp. 31981-31988, Dec. 13, 1996, Enzymatic characterization of Flil.
Heinzerling, HF et al, Infection and immunity, vol. 65(6), p. 2041-2051, Jun. 1997, Genetic and transcriptional analysis of flgB flagellar operon consistuents in teh oral spirocheteTreponema denticolaand their heterologus expression in enteric bacteria.
Minamino, T et al, Journal of Bacteriology, Dec. 1994, pp. 7630-7637, vol. 176(24), Molecular Characterization of theSalmonella typhimuriumflhB Operon and Its protein products.
Venkatesan, MM et al, Journal of Bacteriology, Mar. 1992, vol. 174(6), pp. 1990-2001, Mar. 1992, Surface Presentation ofShigella flexneriInvasion Plasmid Antigens Requires the Products of the spa locus.
McCarter, LL, Journal of Bacteriology, Mar. 1995, vol. 177(6) pp. 1595-1609, Genetic and Moelcular Characterization of the Polar Flagellum ofVibrio parahaemolyticus.
Penner J.L., The GenusCampylobacter: a Decade of Progress. (1988) vol. 1, No. 2 p. 157-172.
Macnab, Robert M. (1992) Genetic and biogenesis of bacterial flagella. vol. 26 pp. 131-158.
Blaser, M.J. and L.B. Reller.(1981)Campylobacter enteritis. vol. 305. No. 24. p. 1444-1452.
Chan, V.L. et al., Cloning and transcription regulation of the ferric uptake regulatory gene ofCampylobacter jejuniTGH9011. (1995) vol. 164, p. 25-31.
Grant, C.C.R. et al., Role of Flagella in Adherence, Internalization, and Translocation ofCampylobacter jejuniin Nonpolirized and Polarized Epithelial Cell Cultures (1993) vol. 61, No. 5, p. 1764-1771.
Guerry, P. et al., Role of Two Flagellin Genes inCampylobacterMotility (1991) 173 (5), p. 4757-4764.
Morooka, T.A. et al., Motility asan Intestinal Colonization Factor forCamylobacter jejuni. (1985) 131, p. 1973-1980.
Wassenaar, T.M. et al., Variation of the flagellin gene locus ofCampylobacter jejuniby recombination and horizontal gene transfer. (1995)141, p. 95-101.
Yao, R. et al., Isolation of motile and non-motile insertional mutants ofCampylobacter jejuni: the role of motiility inb adherence and invasion of eukaryotic cells. (1994) 14 p. 883-893.
Fischer, S.H. and I. Nachamkin. Common and variable domains of the flagellin gene, flaA, inCampylobacter jejuni(1991)5(5), p. 1151-1158.
Josenhans C.A. et al., Comparative Ultrastructural and Functional Studies ofHelicobacter pyloriandHelicobacter mustelaeFlagellin Mutants: Both Flagellin Subunits, FlaA and FlaB, are Necessary for Full Motility inHelicobacter Species. (1995) 77, p. 3010-3020.
Driks,A.R. et al.,The Organization of theCaulobacyer crescentusFlagellar Filament. (1989) 206, p. 627-636.
Pavlovskis, O.R. et al., Significance of Flagella in Colonization Resistance of Rabbits Immunized withCampylobacterpp. (1991) vol. 59, No. 7, pp. 2259-2264.
Macnab, R.M., Flagella and Motility (1996), p. 123-145.
Alm, R.A. et al., Distribution and Polymorphism of the Flagellin Genes from Isolates ofCampylobacter coliandCampylobacter jejuni. (1993) vol. 175 No. 10, pp. 3051-3057.
Khawaja, R.K. et al., Cloning and Sequence Analysis of the Flagellin Gene ofCampylobacter jejuniTGH9011 (1992) vol. 24, pp. 213-221.
Kostrzynska, M. et al., Identification, Characterization, and Spatial Localization of two Flagellin species inHelicobacter pyloriFlagella . (1991) 173, p. 937-946.
McCarter, L.L. Genetic and Molecular Characterization of the Polar Flagellum ofVibrio parahaemolyticus. (1995) 177, p. 1595-1609.
Minnich, S.A. et al., Role of the 25-, 27-, and 29-Kilodalton Flagellins inCaulobacter crescentusCell Motility: Method for Construction of Deletion and Tn5 Insertion Mutants by Gene Replacement. (1988) 70, p. 3953-3960.
Nuijten, P.J.M. et al., Structural and Functional Analysis of TwoCampylobacter jejuniFlagellin Genes (1990) vol. 265 pp. 17798-17804.
Pleier, E. and R. Schmitt. Expression of TwoRhizobium melilotiFlagellin Genes and Their Contribution to the Complex Filament Structure. (1991) vol. 173, No. 6 pp. 2077-2085.
O'Hagan T. D.; Oral Delivery of Vaccines (1992) 22(1) p. 1-10.
Ulmer et al., The Adjuvant effect of Stearyl tyrosine on a recombinant subunit hepatitis B surface antigen. (1993), 2(9) p. 983-989.
Chan et al., (1996) Genbank Accession No. U85622, Abstract.
Taylor, M. F. et al., Mol. Biol. Envol., vol. 10(6), 1259-1272, Genbank Accession No. L16849.
Moon, K. H. et al, J. Micro. Biotechnol., Nol.6, 145-146, Genbank Accession No. U50077.
Wilson et al., Nature vol. 368 (6466), 32-38, Genbank Accession No. U41263 or U21322.
Williams, J.G. et al., EMBO J. vol. 4(4), 999-1006, Abstract, Accession No. X02407.
Lanar et al., Science vol. 234, 593-596, Abstract, Accession No. M14163.
Laclette et al., Mol. Biochem Paras., vol. 44, 287-296, Abstract, Accession No. M35499.
Newell, D.G. et al., Investigations on the role of flagella in the colonization of infant mice withCampylobacter jejuniand attachment ofCampylobacter jejunito human epithelial cell lines. (1985) 95, p. 217-227.
Deres et al., In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine (1989) vol. 342 p. 561-564.
Chang et al., Phenotypic expression inE. coliof a DNA sequence coding for mouse dihydrofolate reductase. (1978) vol. 275, p. 275:617.
Itakura et al., Expression inEscherichia coliof Chemically Synthesized Gene for the Hormone Somatostatin. (1977) 198, p. 1056-1063.
Goeddel et al., Direct expression inEscherichia coliof a DNA sequence coding for human growth hormone (1979) vol. 28, pp. 544-548.
Kim et al., Fine Mapping of the Three rRNA Operons on the Updated Genomic map ofCampylobacter jejuniTGH9011 (ATCC 43431) vol. 175, No. 22. p. 7468-7470.
Nixon-George et al., The adjuvant effect of stearyl tyrosine on a recombinant subunit hepatitis B surface antigen. (1990) 14, p. 4798-4802.
Wieismuller et al., Novel low-molecular-weight synthetic vaccine against foot-and mouth disease containing a potent B-cell and macrophage activator. (1989) vol. 7. p
Chan Voon Loong
Louie Helena
Navarro Mark
Portner Ginny Allen
Sim & McBurney
University of Toronto
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