Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1996-08-13
2000-06-20
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4241851, 4242821, 424 931, 424 934, 435243, 435245, 4352521, A61K 3900, A61K 4500, A01N 6300, C12N 100
Patent
active
060775157
ABSTRACT:
This invention relates to flagella-less strains of Borrelia and to novel methods for use of the microorganisms as vaccines and in diagnostic assays. Although a preferred embodiment of the invention is directed to Borrelia burgdorferi, the present invention encompasses flagella-less strains of other microorganisms belonging to the genus Borrelia. Accordingly, with the aid of the disclosure, flagella-less mutants of other Borrelia species, e.g., B. coriacei, which causes epidemic bovine abortion, B. anserina, which causes avian spirochetosis, and B. recurrentis and other Borrelia species causative of relapsing fever, such as Borrelia hermsii, Borrelia turicatae, Borrelia duttoni, Borrelia persica, and Borrelia hispanica, can be prepared and used in accordance with the present invention and are within the scope of the invention. Therefore, a preferred embodiment comprises a composition of matter comprising a substantially pure preparation of a strain of a flagella-less microorganism belonging to the genus Borrelia.
REFERENCES:
patent: 5523089 (1996-06-01), Bergstrom et al.
Dattwyler et al Annals of The New York Academy of Sciences vol. 539 pp. 93-102, 1988.
Szczepanski et al Microbiological Reviews 55:21-34, 1991.
Sadziene et al Journal of Clin Invest 88:82-92 1991.
Barbour et al Microbiological Reviews 50: 381-400, 1986.
Levine et al Research in Vet. Science 48:64-69 1990.
p. 66, ABST-B-242.
Burgess Annals of the New York Academy of Science 539:235-243, 1988.
Sadziene et al Abstracts of the 91st General Meeting of the American Society for Microbiology p. 66 ABST.-B-243.
Bundoc et al Abstracts of the 91st General Meeting of the American Society for Microbiology.
Barbour Alan G.
Bundoc Virgilio G.
Sadziene Adriadna
Housel James C.
Ryan V.
The University of Texas System & Board of Regents
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