Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1991-01-11
1995-07-25
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4242341, 435243, 435245, 435 732, A61K 3902, A61K 4800, C12N 136
Patent
active
054360005
ABSTRACT:
This invention relates to flagella-less strains of Borrelia and to novel methods for use of the microorganisms as vaccines and in diagnostic assays. Although a preferred embodiment of the invention is directed to Borrelia burgdorferi, the present invention encompasses flagella-less strains of other microorganisms belonging to the genus Borrelia. Accordingly, with the aid of the disclosure, flagella-less mutants of other Borrelia species, e.g., B. coriacei, which causes epidemic bovine abortion, B. anserina, which causes avian spirochetosis, and B. recurrentis and other Borrelia species causative of relapsing fever, such as Borrelia hermsii, Borrelia turicatae, Borrelia duttoni, Borrelia persica, and Borrelia hispanica, can be prepared and used in accordance with the present invention and are within the scope of the invention. Therefore, a preferred embodiment comprises a composition of matter comprising a substantially pure preparation of a strain of a flagella-less microorganism belonging to the genus Borrelia.
REFERENCES:
Webster's Ninth New Collegiate Dictionary, pp. 143, 342 & 1142.
Burgess, Annals of the New York Academy of Science, 539:235-243, 1988.
Barbour et al., Microbiological Rev. 50:381-400, 1986.
Szczepanski et al., Microbiological Rev. 55:21-34, Mar. 1991.
Sadziene et al., Journal of Clinical Invest., 88:82-94, Jul. 1991.
Barbour Alan G.
Bundoc Virgilio
Sidberry Hazel F.
University of Texas System
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