FKBP51/52 and CyP40-mediated mammalian hair growth

Details FKBP51/52 and CyP40-mediated mammalian hair growth FKBP51/52 and CyP40-mediated mammalian hair growth

2007-01-30

2007-01-30

Saunders, David (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C424S009200, C435S007200, C435S007210, C435S007240, C435S007400, C435S029000, C436S501000

Reexamination Certificate

active

10178832

ABSTRACT:
The present invention relates to drug screening assays designed to identify non-immunosuppressive agents that modulate hair growth and the use of such agents for modulation of hair growth.

REFERENCES:
patent: 5763590 (1998-06-01), Peattie et al.
patent: 5837251 (1998-11-01), Srivastava
patent: 5945441 (1999-08-01), Steiner et al.
patent: 5968921 (1999-10-01), Gold
patent: 6187312 (2001-02-01), Srivastava
patent: 6984495 (2006-01-01), Thompson
patent: 2004/0086945 (2004-05-01), Sreekrishna et al.
patent: 11-174041 (1999-07-01), None
patent: WO 98/55090 (1998-12-01), None
patent: WO 99/38965 (1999-08-01), None
patent: WO00/72810 (2000-03-01), None
patent: WO00/72811 (2000-03-01), None
patent: WO00/72812 (2000-03-01), None
patent: WO00/72813 (2000-03-01), None
patent: WO00/72920 (2000-03-01), None
patent: WO00/73292 (2000-03-01), None
Ahmad, Wasim, et al. (1998), “Alopecia Universalis Associated with a Mutation in the Human hairless Gene,” Science, pp. 279, 720.
Bose, Suhira, et al. (1996), “Chaperone Function of Hsp90-Associated Proteins,” Science 274, 1715.
Duina, Andrea A., et al. (1996), “A Cyclophilin Function in Hsp90-Dependent Signal Transduction,” Science 274, 1713.
Heitman, Joseph H., et al. (1992), “Proline Isomerases at the Crossroads of Protein Folding, Signal Transduction, and Immunosuppression,” New Biol. 4:5, 448.
Iwabuchi, Tokuro, et al. (1995), J. Dermatol. Sci. 9, 64.
Lane, W.S., et al. (1991), “Complete Amino Acid Sequence of the FK506 and Rapamycin Binding Protein, FKBP, Isolated from Calf Thymus,” J. Protein Chem. 10:2, 151.
Maurer, Marcus, et al. (1997), “Hair Growth Modulation by Topical Immunophilin Ligands,” Amer. J. Path. 150:4, 1433.
Miyata, Yoshihiko, et al. (1997), “Phosphorlyation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: Regulation of HSP90-binding activity of FKBP52,” Proc.Natl.Acad.Sci.USA 94, 14500.
Nair, Satish C., et al. (1997), “Molecular Cloning of Human FKBP51 and Comparisons of Immunophilin Interactions with Hsp90 and Progesterone Receptor,” Mol.Cell.Biol. 17:2, 594.
Owens-Grillo, Janet K., et al. (1995), “The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor,” J.Biol.Chem. 270:35, 20479.
Pratt, William B., et al. (1999), “A Model for the Cytoplasmic Trafficking of Signalling Proteins Involving the hsp90-Binding Immunophilins and p50cdc37,” Cell.Signal 11:12, 839.
Pratt, William B., et al. (1997), “Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones,” Endoctrine Reviews 18:3, 306.
Sainsbury, T.S.L., et al. (1991), “Differential Effects of FK 506 and Cyclosporine of Hair Regrowth in the DEBR Model of Alopecia Areata,” Transplantation Proceedings 23:6, 3332.
Silverstein, Adam, M., et al. (1999), “Different Regions of the Immunophilin FKBP52 Determine Its Association with the Glucocorticoid Receptor, hsp90, and Cytoplasmic Dynein,” J.Biol.Chem. 274:52, 36980.
Smith, David F., et al. (1993), “Two FKBP-related Proteins Are Associated with Progesterone Receptor Complexes,” J.Biol.Chem. 268:24, 18365.
Yamamoto, Satoshi, et al. (1994), “Stimulation of Hair Growth by Topical Application of FK506, a Potent Immunosuppressive Agent,” J.Invest.Dermatol. 102:2, 160.
Yamamoto, Satoshi, et al. (1994), “Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants,” J.Dermatol.Sci. 7(Suppl.), S47.
Bradbury, “Molecular help on the horizon for hair loss?” The Lancet, 2001, pp. 1346, vol. 358, No. 9290.
Gold BG et al. (1999) J. Pharmacol. Exp. Ther. 289:1202.
Hashizume H et al. (1997) J. Dermatol. 36:587.
Pratt WB et al. (1993) J. Steroid Biochem Mol. Biol. 46:269.
Segnitz B and Gehring U (1997) J. Biol Chem 272:18694.
Tai PK et al. (1994) Biochemistry 33:10666.
Tsuji Y et al. (1999) Exp. Dermatol. 8(4):366.

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