Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-05-05
1991-01-22
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514183, 540455, 540457, A61K 31445, C07D49816
Patent
active
049871390
ABSTRACT:
Described is a new immunosuppressant, L-687,795, a C-13, C-15, C-31 trisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 3244592 (1966-04-01), Arai
Arai et al., "J. Antibiotics", vol. A15, pp. 231-232 (1962).
Arison Byron H.
Chen Shieh-Shung T.
Wicker Linda S.
Bond Robert T.
Merck & Co. , Inc.
North Robert J.
Pfeiffer Hesna J.
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