FK-506 C10-C18 process intermediates

Details FK-506 C10-C18 process intermediates FK-506 C10-C18 process intermediates

1991-05-16

1992-10-13

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548110, 556411, 556443, 556449, 556482, 560 8, 560112, 564224, 568626, 568659, 568679, 568680, C07D26304

Patent

active

051552280

ABSTRACT:
A process is described for the improved synthesis of the optically pure C.sub.10 -C.sub.18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.

REFERENCES:
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 4940797 (1990-07-01), Jones et al.
patent: 5012000 (1991-04-01), Illig et al.
patent: 5068345 (1991-11-01), Illig et al.

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