Five-membered ring systems with bonded imidazolyl ring substitue

Details Five-membered ring systems with bonded imidazolyl ring substitue Five-membered ring systems with bonded imidazolyl ring substitue

1990-03-08

1992-08-18

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514324, 548131, 548235, 548238, 548239, C07D41314, A61K 3141, A61K 3142

Patent

active

051400340

ABSTRACT:
A class of 5-membered heterocyclic compounds having at least one heteroatom, substituted on the heterocyclic ring by an imidazolyl moiety, are useful in the treatment of psychotic disorders (e.g. schizophrenia and mania); anxiety; alcohol or drug withdrawal or dependence; pain; gastric stasis; gastric dysfunction (such as occurs with dyspepsia, peptic ulcer, reflux oesophagitis and flatulence); migraine, nausea and vomiting; movement disorders; and presenile and senile dementia.

REFERENCES:
patent: 4914207 (1990-04-01), Nagel
patent: 4963689 (1990-10-01), Nagel
Chem. Ber., 1957, 90, 182.
Synthesis, 1975, 389.
Advances in Heterocyclic Chemistry, 1970, 12, 104.
Nature, 1985, 316, 126.
Br. J. Pharmacol., 1988, 93, 985.
Eur. J. Pharmacol., 1987 138 303.
Eur. J. Pharmacol., 1988, 149, 397.
J. Med. Chem. 33(1) 13-16 (1990) (Pfizer).

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