Five-membered cyclic compounds

Details Five-membered cyclic compounds Five-membered cyclic compounds

2008-07-08

2008-07-08

Shiao, Rei-Tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S235500, C546S269700, C544S124000, C544S133000

Reexamination Certificate

active

11111845

ABSTRACT:
A 5-membered cyclic compound of the formula:wherein X is oxygen or sulfur, R1is hydrogen, substituted or unsubstituted alkyl, etc., R2is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3is substituted or unsubstituted aryl, etc., Y2is substituted or unsubstituted alkylene, etc., R4is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.

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