Fish insulin-like growth factor 11 promoter

Details Fish insulin-like growth factor 11 promoter Fish insulin-like growth factor 11 promoter

1998-07-20

2000-01-25

Campbell, Bruce R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 241, 4353201, 800 25, C07H 2102, C07H 2104, C12N 1500

Patent

active

060180404

ABSTRACT:
This present invention relates to the findings of the DNA sequences of fish insulin-like growth factor II (IGF-II) promoter regions and recombinant IGF-II promoters. These DNA sequences are capable of being expressed in eukaryotic cells and fish embryos of another fish species. The integration of the IGF-II promoter regions or recombinant IGF-II promoters into fish of another species results in the creation of a transgenic fish. The results of this invention illustrate that a fish IGF-II promoter not only can act as a growth factor to stimulate the growth and development of fish, but also is capable of being expressed in other eukaryotic cells such as in human cells.

REFERENCES:
Chen et al. Isolation and Characterization of Tilapia (Oreochromis mossambicus) Insulin-Like Growth Factors Gene and Proximal Promoter Region, DNA and Cell Biology: 17, 359-376, 1998.
Chen et al. Fish Insulin-like Growth Factors and Their Industrial Applications, Bioindustry: 9, 1998.
Chen et al. Production of Biologically Active Recombinant Tilapia Insulin-Like Growth Factor-II Polypeptides in Escherichia coli Cells and Characterization of the Genomic Structure of the Coding Region, DNA and Cell Biology, 16, 883-892, 1997.
Gray et al. Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene, DNA 6: 283-295, 1987.
Koval et al. Characterization of a Salmon Insulin-Like Growth Factor I Promoter, DNA and Cell Biology: 13, 1057-1062, 1994.
Kulik et al. The Promoter of the Salmon Insulin-like Growth Factor I Gene is Activated by Hepatocyte Nuclear Factor 1, JBC: 270, 1068-1073, 1995.
Hall et al. Functional Analysis of the Rat Insulin-Like Growth Factor I Gene and Identification of an IGF-I Gene Promoter, DNA and Cell Biology: 11, 301-313, 1992.
Kavsan et al. Structure of the Chum Salmon Insulin-Like Growth Factor I Gene, DNA and Cell Biology: 12, 729-737, 1993.
Kim et al. Structure and Function of a Human Insulin-like Growth Factor-I Gene Promoter, Molecular Endocrinology: 5, 1964-1972, 1991.
Chen et al., GenBank Accession No. AF033802, May 1998.
Chen et al., DNA and Cell Biology, vol 17(4), p. 359-76, Apr. 1998.
Shamblott and Chen, GenBank Accession No. M95184, Nov. 1992.
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