Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-11-21
1999-11-30
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 530326, 424405, 536 235, 4352523, 4353201, A61K 3804, A01N 2500, C12N 1512, C12N 1513
Patent
active
059943068
ABSTRACT:
The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections.
REFERENCES:
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4652639 (1987-03-01), Stabinsky
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5087569 (1992-02-01), Gabay et al.
patent: 5102870 (1992-04-01), Florine et al.
patent: 5126257 (1992-06-01), Gabay et al.
patent: 5171739 (1992-12-01), Scott et al.
patent: 5234912 (1993-08-01), Marra et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
patent: 5338724 (1994-08-01), Gabay et al.
patent: 5432270 (1995-07-01), Zasloff et al.
patent: 5447914 (1995-09-01), Travis et al.
patent: 5458874 (1995-10-01), Pereira et al.
patent: 5459235 (1995-10-01), Selsted et al.
patent: 5464823 (1995-11-01), Lehrer et al.
patent: 5484885 (1996-01-01), Pereira et al.
patent: 5607916 (1997-03-01), Periera et al.
patent: 5693486 (1997-12-01), Lehrer et al.
patent: 5708145 (1998-01-01), Lehrer et al.
Simmaco, M., et al., The Journal of Biological Chemistry, vol. 269, "Antimicrobial peptides from skin secretions of Rana esculenta", pp. 11956-11961, 1994.
Bateman et al. 1992, "The levels and biologic action of the human neutrophil granule peptide HP-1 in lung tumors,"Peptides 13:133-139.
Bilgrami, S. et al., 1992, "Capnocytophaga Bacteremia in Patient with Hodgkin's Disease following Bone Marrow Transplantation: Case Report and Review," Clinical Infectious Diseases 14:1045-1049.
Broekaert et al., 1992, Biochemistry 31:4308-4314.
Cornelissen et al., 1993, Plant Physiol. 101:709-712.
Diamond et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88:3952-3956.
Donnelley, J.P. et al., 1993, "Failure of Clindamycin to Influence the Course of Severe Oromucostis Associated with Streptococcal Bactaeremia in Allogeneic Bone Marrow Transplant Recipients," Scand J. Infect. Dis. 25:43-50.
Elsbach et al., 1993, Current Opinion in Immunology 5:103-107.
Haln et al., 1993, Nature 361:153-156.
Harwig et al., 1994, "Gallacins: cysteine-rich antimicrobial peptides of chicken leukocytes," FEBS Lett. 342:281-285.
Harwig et al., 1995, J. Peptide Sci. 3:207-215.
Harwig et al., 1995, FEBS Lett. 362:65-69.
Hoess et al., 1993, EMBO Journal 12:3351-3356.
Kokryakov et al., 1993, FEBS Lett. 327:231-236.
Lambert et al., 1989, Proc. Natl. Acad. Sci. U.S.A. 88:262-265.
Lehrer et al., 1985, J. Virol. 54:467-472.
Lehrer et al., 1991, Cell 64:229-230.
Lehrer et al., 1993, Ann. Rev. Immunol. 11:105-128.
Lerner, 1982, Nature 299:592-596.
Maloy & Kari, 1995, "Structure-activity studies on maganins and other host defense peptides," Biopolymers (Peptide Science) 37:105-122.
Masera et al., 1996, "Corticostatins/defensins inhibit in vitro NK activity and cytokine production by human peripheral blood mononuclear cells," Regulatory Peptides 62:13-21.
Masuda et al., 1992, "A novle anti-HIV synthetic peptide T-22 ([Tyr5, 12, Lys7]-polyphemusin II)," Biochem. Biophys. Res. Commun. 189:845-850.
Matsumoto et al., 1982, Chem. and Pharma. Bulletin 40(10):2701-2706.
Matsuzaki et al., 1991, "Interactions of an antimicrobial peptide, tachyplesin I, with lipid membranes," Biochim. Biophys. Acta 1070:259-264.
Matsuzaki et al., 1993, Biochemistry 32:11704-11710.
Mirgorodskaya et al., 1993, FEBS Lett. 330:339-342.
Miyata et al., 1989, J. Biochem. 106:663-668.
Morimoto et al., 1991, Chemotherapy 37:206-211.
Murakami et al., 1991, Chemotherapy 37:327-334.
Nakamura et al., 1988, J. Biol. Chem. 263:16709-16713.
Nakashima et al., 1992, Antimicrobial Agents and Chemotherapy pp. 1249-1255.
Olsson et al., 1991, Biochim. Biophys. Acta 1097:37-44.
Park et al., 1992, "Conformation of tachyplesin I from Tachypleus tridentatus when interacting with lipid matrices," Biochemsitry 31:12241-12247.
Pongor et al., 1987, Methods in Enzymology 154:450-473.
Robson et al., 1986, Introduction to Proteins and Protein Engineering, Elksevier, New York, p. 41.
Rustici et al., 1993, Science 259:361-364.
Schulesener et al., 1993, "Leukocyte antimicrobial peptides kill autoimmune T cells," Journal of Neuroimmunology 47:199-202.
Selsted et al., 1985, J. Biol. Chem. 260(8):4579-4584.
Selsted et al., 1992, "Enteric defensins: Antiobiotic peptide components of intestinal host defense," J. Cell Biol. 118:929-936.
Selsted et al., 1993, J. Biol. Chem. 268:6641-6648.
Storici et al., 1993, Biochem. Biophys. Res. Commun. 196:1363-1368.
Tamamura et al., 1993, "Antimicrobial activity and conformation of tachyplesin I and its analogs," Chemical and Pharmaceutical Bulletin 41:978-980.
Tamamura et al., 1993, "A comparative study of the solution structure of tachyplesin I and a novel anti-HIV synthetic peptide, T22, determined by nuclear magnetic resonance," Biochim. Biophys. Acta 1163:209-216.
Tamamura et al., 1995, "Synthesis of protegrin-related peptides and their antibacterial and anti-Human Immunodeficiency Virus activity," Chemical and Pharmaceutical Bulletin 43:853-858.
Zhao et al., 1994, FEBS Lett. 346:285-288.
Zhao et al., 1995, FEBS Lett. 368:197-202.
Zhao et al., 1995, FEBS Lett. 376:130-134.
Harwig, S. S.L. et al., 1996, "Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations," Eur. J. Biochem. 240:352-357.
Yasin, B. et al., 1996, "Protegrins: Structural requirements for inactivating elementary bodies of Chlamydia trachomatis," Infection and Immunity 64(11):4863-4866.
Chang Conway C.
Chen Jie
Gu Chee Liang
Harwig, deceased Sylvia S.L.
Lehrer Robert I.
Achutamurthy Ponnathapura
IntraBiotics Pharmaceuticals, Inc.
Moore William W.
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