Fine-milled colestipol hydrochloride

Details Fine-milled colestipol hydrochloride Fine-milled colestipol hydrochloride

1994-08-03

1996-05-28

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424439, 424440, 424452, 424465, 514952, 264140, A61K 914

Patent

active

055209327

ABSTRACT:
The present invention provides a novel fine milled form of a known pharmaceutical composition, colestipol hydrochloride. This fine milled form of colestipol hydrochloride yields pharmaceutically elegant dosage forms exhibiting increased potency, including non-gritty oral powders and high dose oral tablets (e.g., 1000 mg tablets). Conventional colestipol hydrochloride was heretofore available in spherical granules which produced less elegant (gritty) oral suspensions and oral tablets with substantially lower doses of drug (e.g., ca 500 mg).

REFERENCES:
patent: 3692895 (1972-09-01), Nelson et al.
patent: 3803237 (1974-04-01), Lednicer et al.
patent: 3846541 (1974-11-01), Howard
patent: 4404346 (1983-09-01), Pirotta et al.
patent: 4439419 (1984-03-01), Vecchio
patent: 4631305 (1986-12-01), Guyer et al.
patent: 4814354 (1989-03-01), Ghebre-Sellassie
patent: 4917309 (1990-04-01), Zander et al.
patent: 5174512 (1992-12-01), Orlandi
Physician's Desk Reference (PDR), 42nd Edition, pp. 2115-2116, 1988.
Grant & Hackh's Chemical Dictionary 5th ed, Pub. McGraw-Hill p. 370.

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